Malaysian Journal of Analytical Sciences Vol 23 No 5 (2019): 789 - 798

DOI: 10.17576/mjas-2019-2305-04

 

 

 

SPECTROSCOPIC STUDIES OF INCLUSION COMPLEX GLIPIZIDE AND β-CYCLODEXTRIN

 

(Kajian Spektroskopik Kompleks Kemasukan Glipizida dan β-siklodekstrin)

 

Nurul Yani Rahim*, Fatin Hamizah Samad, Asmaa’ Mardhiah Rohisham

 

School of Chemical Sciences,

Universiti Sains Malaysia,

11800 Gelugor, Pulau Pinang, Malaysia

 

*Corresponding author:  nurulyanirahim@usm.my

 

 

Received: 8 May 2019; Accepted: 3 September 2019

 

 

Abstract

The complex between hypoglycemic drug, glipizide, and β-cyclodextrin (β-CD) was prepared using the kneading method with aliquot addition of ethanol. The product was characterized using Fourier Transform Infrared (FTIR) spectrometer and Thermogravimetric Analysis (TGA). ¹H and NOESY Nuclear Magnetic Resonance (NMR) and UV-Vis spectroscopy were used to determine the interaction involved in the formation of inclusion complex β-CD/glipizide. ¹H and NOESY NMR results indicated that the hydrophobic interaction occurred between glipizide and β-CD. The formation constant values of complex β-CD/glipizide at pH 9 and 4 were close to each other. The stoichiometry ratio for the inclusion complex between β-CD with glipizide was 1:1.

 

Keywords:  β-CD, antidiabetic drug, formation constant, cavity, kneading

 

Abstrak

Kompleks antara ubat hipoglisemia, glipizida, dan β-siklodekstrin (β-CD) telah disediakan dengan cara menguli bersama penambahan etanol alikuot. Produk ini dicirikan menggunakan spektrometer inframerah transformasi Fourier (FTIR) dan analisis termogravimetrik (TGA). Resonan Magnetik Nuklear (NMR) ¹H dan NOESY dan spektroskopi UV-Vis telah digunakan untuk menentukan interaksi yang terlibat dalam pembentukan kompleks kemasukan β-CD/glipizida. Hasil NMR ¹H dan NOESY menunjukkan bahawa interaksi hidrofobik berlaku antara glipizida dan β-CD. Nilai pemalar pembentukan kompleks β-CD/glipizida pada pH 9 dan 4 adalah lebih kurang sama. Nisbah stoikiometri untuk kompleks kemasukan antara β-CD dan glipizida ialah 1: 1

 

Kata kunci:  β-CD, ubat antidiabetik, pemalar pembentukan, kaviti, menguli

 

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