Sains Malaysiana 39(5)(2010): 737–745
Sifat Fizikal dan Kajian In Vitro Tablet
Matriks Pelepasan Tertahan Ketoprofen
(Physical
Properties and In Vitro Studies of Sustained-Release Ketoprofen Matrix Tablets)
Ibrahim Ijang
Bahagian Teknologi Perubatan, Agensi
Nuklear Malaysia, Bangi
43000 Kajang, Selangor D.E., Malaysia
Mohd Cairul Iqbal Mohd Amin*, Bukhori
Abu Bakar
Fakulti Farmasi, Universiti
Kebangsaan Malaysia
Jalan Raja Muda Abdul Abdul Aziz,
50300 Kuala Lumpur, Malaysia
Diserahkan: 3 Februari 2009 / Diterima:
20 Januari 2010
ABSTRAK
Penggunaan
formulasi tablet pelepasan tertahan untuk dadah anti-inflamatori bukan steroid
(DAIBS) seperti aspirin berupaya
melindungi lapisan perut dari kesan buruk jus asid tubuh. Kajian ini dilakukan
untuk menilai keberkesanan formulasi tablet matriks pelepasan tertahan dengan
kepelbagaian kepekatan polimer bersama ketoprofen sebagai model. Tablet
dibangunkan dengan menggunakan kaedah granulasi basah yang terdiri daripada
polimer hidrofilik (hidroksipropil metilselulosa), polimer hidrifobik bersandar
pada pH (Eudragit L100-55) dan polimer tak bersandar pada pH (Eudragit R100)
sebagai bahan asas pembentukan matriks pada kepekatan 10%, 20% dan 30%b/b.
Semua formulasi dimampatkan dengan menggunakan mesin pentabletan yang mempunyai
penebuk berbentuk cembung bersaiz 10 mm. Tablet yang terhasil diuji dari segi
keseragaman berat, kekerasan, kerapuhan, ketebalan, % kandungan dadah dan
kajian pelepasan in vitro menggunakan kaedah BP 2007. Hasil menunjukkan kadar
pelepasan dadah dikawal oleh jenis dan kepekatan polimer di dalam formulasi
matriks. Secara umumnya peningkatan kepekatan kandungan polimer di dalam tablet
matriks didapati mengurangkan kadar pelepasan dadah. Perbandingan polimer
melalui kepekatan yang sama menggunakan t50%, pula mendapati terdapat perbezaan statistik bermakna
(P<0.05) pada kadar pelepasan dadah. Berdasarkan kepada pelepasan dadah
dalam kajian in vitro, polimer hidrofobik bersandar pada pH (Eudragit L100-55)
menunjukkan profil pelepasan dadah secara tertib sifar yang terbaik berbanding
polimer yang lain.
Kata kunci:
Pelepasan tertahan; tablet matriks; ketoprofen; pelepasan in vitro
ABSTRACT
The use of
sustained release tablet formulation for non-steroidal anti-inflammatory drugs
(NSAIDs) like aspirin has shown its
capability to protect the stomach lining from the adverse effect of gastric
juice from the body. This study was carried out to evaluate the efficiency of
sustained release matrix tablet formulation using ketoprofen as a model drug
with different polymers concentration. The tablets were prepared by the wet
granulation method using hydrophilic polymer (hydroxypropyl methylcellulose),
hydrophobic pH dependent polymer (Eudragit L100-55) and independent polymer
(Eudragit RD 100) as matrix forming retarding
materials at 10%w/w, 20%w/w and 30%w/w. All formulations were compressed using
10 mm concave faced punches. The compressed tablets were evaluated for
uniformity of weight, friability, hardness, thickness, % drug content and in vitro dissolution test with regard to BP 2007. The results showed that the drug release rate was found to
be governed by the type and concentration of polymer in the matrix system.
Generally, increasing the polymeric concentration in the matrix tablets will
decrease the rate of drug release. When the polymers were compared at similar
concentration using t50%, the
difference in drug release was found to be statistically significant
(p<0.05). Based on the in vitro drug dissolution studies, the hydrophobic pH
dependent polymer (Eudragit L100-55) showed a better zero drug release profile
compared to other polymers.
Keywords: in vitro dissolution; ketoprofen; matrix tablets; sustained
release
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*Pengarang
untuk surat-menyurat: email: mciamin@pharmacy.ukm.my
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