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Sains Malaysiana 44(2)(2015): 301–308
Modeling of the Dissolution Kinetics of Arbutus Wild Berries-Based Tablets as Evaluated by Electric Conductivity (Permodelan
Pembubaran Kinetik Arbutus Beri Liar Berasaskan Tablet Dinilai oleh
Kekonduksian
Elektrik)
TOUNSIA ABBAS-AKSIL
& SALEM BENAMARA*
Research
Laboratory in Food Technology (LRTA), Faculty of Engineering Science University
M'hamed Bougara of Boumerdès, 35000 Boumerdès, Algeria
Diserahkan: 23 April
2013/Diterima: 5 Ogos 2014
ABSTRACT
Lyophilized powder (LP)
from Algerian arbutus wild berries (Arbutus
unedo L.) was obtained. This present paper reports about the dissolution
(releasing) properties of LP-based tablets, evaluated through
the electric conductivity (EC) of distilled water which is employed as
surrounding medium, at three different temperatures (291, 298 and 309 K). In
addition to this, secondary physicochemical characteristics such as elementary
analysis, color and compressibility were evaluated. Regarding the modeling of
ionic transfer, among the three tested models, namely Peleg, Singh et al. and
Singh and Kulshestha, the latter seems to be the most appropriate (R2 =
0.99), particularly in the case of compacted tablets under 2000 Pa. The
temperature dependence of the dissolution process was also studied applying
Arrhenius equation (R2>0.8) which allowed to deduce the
activation energy, ranging from 18.7 to 21.4 kJ.mol-1 according
to the model and compression force employed.
Keywords: Arbutus wild
berries (Arbutus unedo L.); dissolution; electric conductivity;
powder; tablet
ABSTRAK
Serbuk lyophilized (LP)
dari Arbutus beri liar Algeria (Arbutus unedo L.)
telah diperoleh. Kertas ini melaporkan tentang sifat pembubaran
(pelepasan) tablet berasaskan LP, dinilai melalui kekonduksian elektrik
(EC) air suling yang digunakan sebagai medium kelilling,
pada 3 suhu yang berbeza (291, 298 dan 309 K). Di samping itu, ciri
fizikokimia sekunder seperti analisis asas, warna dan kadar mampatan
telah dinilai. Mengenai model pemindahan ionik, antara tiga model
yang diuji ialah Peleg, Singh et al. dan Singh dan Kulshestha, dengan
yang terakhir paling sesuai (R2
= 0,99), terutamanya dalam kes tablet yang dipadatkan
di bawah 2000 Pa. Pergantungan suhu dalam proses pembubaran juga
dikaji menggunakan persamaan Arrhenius (R2> 0.8) yang dibenarkan untuk menyimpulkan tenaga pengaktifan,
antara 18.7 hingga 21.4 kJ.mol-1 mengikut
model dan mampatan daya yang digunakan.
Kata kunci: Arbutus beri liar (Arbutus unedo L.);
kekonduksian elektrik; pembubaran; serbuk; tablet
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*Pengarang untuk surat-menyurat; email: sbenamara2001@yahoo.fr
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