Sains Malaysiana 46(10)(2017): 1877–1886
http://dx.doi.org/10.17576/jsm-2017-4610-26
Observation of Tumour-induced
Reorganization in Structural and Functional Architecture of the Brain in Three
Pre-surgical Patients with Left Frontal-temporal Brain Tumour:
A Combination of MEG, DTI and
Neuropsychological Assessment
(Pemerhatian Tumor Menyebabkan Perubahan pada Struktur dan Fungsi Otak dalam Tiga Pesakit Pra-pembedahan yang menghidap Tumor Otak pada Bahagian Frontal-Temporal: Kombinasi MEG, DTI dan Penilaian Neuropsikologi)
HANANI ABDUL MANAN1*, ZAMZURI IDRIS2,3, MOHAMMED FARUQUE REZA3, WAN NOR AZLEN WAN MOHAMAD3 & JAFRI MALIN ABDULLAH2
1Department of Radiology, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia
2Center
for Neuroscience Service and Research, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan Darul Naim, Malaysia
3Department
of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan Darul Naim, Malaysia
Diserahkan: 3 Januari 2017/Diterima: 29
September 2017
ABSTRACT
Visual function is
mainly located within the bilateral hemisphere of the occipital lobes of the
brain. However, our functional magnetoencephalography (MEG)
result has demonstrated the reorganization of brain activity in the occipital
area in patients with left-sided brain tumour. The
results showed that brain laterality changes from bilateral to unilateral
activation of the occipital area. Right occipital area (contralateral areas to
the tumour), shows increase intensity of activation.
Diffusion tensor imaging (DTI) with fibre tracking was performed to further investigate this brain laterality
modification and the findings confirmed there is an alteration in the left
hemisphere fibre optic tracts. This functional
modification and changes of the brain laterality and optic tracts in the brain
is suspected to be the result of tumour growth
induced changes. The present observation will be discussed in term of the
mechanism of tumour induced reorganization and
changes with the corroborating evidence from MEG, DTI and
neuropsychological assessment.
Keywords: Diffusion
tensor imaging; magnetoencephalography; neuroplasticity; visual evoked field
and functional shifted
ABSTRAK
Fungsi visual terletak pada kedua-dua belah bahagian hemisfera lobus osipital. Walau bagaimanapun, hasil kajian kefungsian dengan menggunakan magnetoensefalografi (MEG) menunjukkan berlakunya pengubahsuaian pada pengaktifan otak bagi pesakit yang menghidap tumor pada sebelah kiri otak. Keputusan menunjukkan pengaktifan unilateral pada pesakit tersebut iaitu pada sebelah kontralateral pada bahagian tumor. Keputusan kajian ini turut disokong oleh keputusan daripada pengimejan tensor resapan (DTI). Keputusan daripada pengimejan DTI turut menunjukkan terdapatnya perubahan pada optik fiber pada sebelah kiri hemisfera. Perubahan kefungsian dan perubahan pada optik fiber ini dicadangkan disebabkan oleh tumor. Keputusan pemerhatian ini akan dibincangkan daripada segi makanisme keplastikan neuro dengan menghubungkan bukti daripada pengimejan MEG, DTI dan ujian psikologi.
Kata kunci: Keplastikan neuro; magnetoensefalografi; pengimejan tensor resapan; rangsangan medan penglihatan dan kefungsian teranjak
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*Pengarang untuk surat-menyurat;
email: hanani@ukm.edu.my