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Sains Malaysiana 50(7)(2021): 1997-2006
http://doi.org/10.17576/jsm-2021-5007-14
The Effect of Type, Duration and Intensity of Exercise on Inflammatory
MarkersCRP, IL-6 and IL-18 in Metabolic Syndrome
Patients: A Systematic Review
(Kesan Jenis, Tempoh dan Keamatan Senaman terhadap Penanda RadangCRP, IL-6 and IL-18 pada Pesakit Sindrom Metabolik: Suatu Tinjauan Sistematik)
SRIJIT
DAS1, ISA NAINA-MOHAMED2, MOHAMED S ZULFARINA2,
HAZWAN HAZRIN SALIM3, AZWANI ZAWAWI3,
TARRSINI THEVARAJ3, KU NURMAHIRAH KU-AHMAD-NASIR3 &
DENNIS KHENG ZHOU3
& SEONG LIN TEOH3*
1Department of Human & Clinical Anatomy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat 123, Sultanate of Oman
2Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia
3Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia
ABSTRACT
Metabolic syndrome (MetS)
has become a major clinical challenge worldwide due to rise of urbanisation,
surplus energy intake, increasing obesity and sedentary lifestyle. C-reactive
protein (CRP), interleukin-6 (IL-6) and interleukin-18 (IL-18) are associated
with MetS. We performed a systematic review to
investigate the effects of exercise on these markers in MetS patients and therefore to determine the best exercise regime for them. We
searched Medline (Pubmed and Ovid), Scopus and CINAHL
databases. The searches were standardized by using the same search strategy
which included the terms such as ‘metabolic syndrome’, ‘CRP’, ‘IL-6’, ‘IL-18’
and ‘exercise’. Only clinical human studies published from Jan 2007 to May 2018
were included. A total of 11 clinical trials (466
participants) were selected. Majority of the studies were randomized controlled
studies (90.9%). All studies showed a decrease in serum levels of the
biomarkers. However, not all were statistically significant. The main type of
exercise in most of the studies was aerobic. Aerobic-resistance exercise was
more effective rather than aerobic alone, but aerobic exercise was the only
effective as a sole intervention. Aerobic exercise showed promising role as the
main lifestyle intervention in MetS. It is concluded
that patients with MetS should have combined
aerobic-resistance exercise.
Keywords: c-reactive protein; exercise; IL-6; IL-18;
metabolic syndrome
ABSTRAK
Sindrom metabolik (MetS) telah menjadi cabaran klinikal utama di seluruh dunia akibat kemajuan perbandaran, pengambilan tenaga yang berlebihan, peningkatan kadar obesiti dan gaya hidup yang tidak aktif. Penanda seperti protein C-reaktif (CRP), interleukin-6 (IL-6) dan interleukin-18 (IL-18) telah dikaitkan dengan MetS. Kami menjalankan ulasan sistematik untuk mengkaji kesan senaman kepada penanda ini pada pesakit MetS dan juga untuk mengetahui rejim senaman yang terbaik untuk mereka.
Carian telah dijalankan melalui pangkalan data Medline (Pubmed dan Ovid), Scopus dan CINAHL. Carian telah diseragamkan dengan menggunakan strategi pencarian yang sama termasuk istilah seperti ‘sindrom metabolik’, ‘CRP’, ‘IL-6’, ‘IL-18’ dan ‘senaman’. Hanya kajian klinikal yang diterbitkan dari Jan 2007 hingga Mei 2018 termasuk dalam kajian ini. Sebanyak 11 kajian klinikal (466 peserta) telah dipilih. Majoriti kajian adalah kajian terkawal rawak (90.9%). Semua kajian menunjukkan penurunan kadar penanda dalam serum. Walau bagaimanapun, tidak semuanya menunjukkan perbezaan yang signifikan. Jenis utama senaman dalam kajian terlibat adalah senaman aerobik. Senaman rintangan-aerobik adalah lebih berkesan berbanding senaman aerobik, tetapi hanya senaman aerobik merupakan intervensi yang berkesan jika dilakukan secara tunggal. Senaman aerobik berpotensi dijadikan intervensi gaya hidup utama dalam MetS. Disimpulkan bahawa pesakit MetS memerlukan gabungan senaman rintangan-aerobik.
Kata kunci: IL-6; IL-18; senaman; sindrom metabolik; protein c-reaktif
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*Pengarang untuk surat-menyurat; email:
teohseonglin@ppukm.ukm.edu.my
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