Malaysian Journal of Analytical Sciences Vol 19 No 6 (2015): 1290 - 1296

 

 

 

CHARACTERIZATION OF CROSSLINKED ZERUMBONE LOADED GELATIN – ZEOLITE Y HYBRID COMPOSITES WITH GLUTARALDEHYDE FOR CONTROLLED RELEASE OF NATURAL ANTICANCER DRUG

 

(Pencirian Sambung Silang Zerumbon Dimuatkan dalam Gelatin-Zeolit Y Komposit Hibrid dengan Glutaraldehid untuk Pembebasan Terkawal Ubat Anti-Kanser Semulajadi)

 

Norashikin Salleh¹, Umi Sarah Jais¹*, Siti Halimah Sarijo²

 

¹Materials Technology

²Applied Chemistry

Faculty of Applied Sciences,

Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

 

*Corresponding author: umisarah@salam.uitm.edu.my

 

 

Received: 23 November 2014; Accepted: 3 September 2015

 

 

Abstract

Zeolite Y-gelatin hybrid spherical pellets were prepared by blending zerumbone loaded zeolite Y with gelatin solution and crosslinking achieved by glutaraldehyde. The pellets were characterized by using ATR-FTIR spectroscopy, Raman spectroscopy, thermogravimetric analysis (TGA) and swelling analysis. The zerumbone entrapment in zeolite Y was calculated via UV-VIS and results showed that zerumbone could be encapsulated to the maximum loading of porous zeolite Y. ATR-FTIR analysis showed the inert property of zeolite Y that only act as porous host carrier and crosslinking was achieved at 1650 cm^-1. Result from Raman spectra supported and proven that crosslinking occur at 1650 cm^-1. The swelling of crosslinked samples showed slower water penetration indicating that crosslinking had strengthened the spherical pellets. TGA results supported that after crosslinking took place, the thermal decomposition temperature for the composite increased indicating the increase of composite strength. This study showed promising results towards the composite development in controlled drug release area.

 

Keywords: controlled drug delivery, gelatin, zeolite Y, zerumbone, glutaraldehyde

 

Abstrak

Pellet sfera dari hybrid zeolit Y-gelatin telah disediakan dengan menggbungkan zerumbon yang dimuatkan di dalam zeolit Y ke dalam campuran gelatin dan sambung silang dicapai dengan menggunakan glutaraldehid. Pelet dicirikan dengan menggunakan ATR-FTIR spektroskopi, Raman spektroskopi, analisis termogravimetri (TGA) dan analisis penyerapan. Pemerangkapan zerumbon di dalam zeolit Y dianalisis melalui UV-VIS dan keputusan menunjukkan bahawa zerumbon boleh dimuatkan secara maksimum di dalam liang zeolit Y. ATR-FTIR menunjukkan sifat lengai zeolit Y yang hanya bertindak sebagai ‘pembawa’ berliang dan silang sambung dicapai pada 1650 cm^-1. Keputusan dari spectrum Raman menyokong dan turut membuktikan bahawa silang sambung berlaku pada 1650 cm^-1. Penyerapan sampel silang menunjukkan penembusan air secara perlahan-lahan lantas membuktikan bahawa silang sambung telah mengukuhkan pelet sfera. Keputusan TGA menyokong bahawa selepas silang sambung berlaku, suhu penguraian haba bagi komposit meningkat dan membuktikan peningkatan kekuatan komposit. Kajian ini menunjukkan keputusan yang memberangsangkan terhadap pembangunan komposit dalam pembebasan ubat secara terkawal.

 

Kata kunci: perlepasan ubat terkawal, gelatin, zeolite Y, zerumbon, glutaraldehid

 

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