Malaysian Journal of Analytical Sciences Vol 20 No 6 (2016): 1515 - 1523

DOI: http://dx.doi.org/10.17576/mjas-2016-2006-33

 

 

 

SYNTHESIS AND CHARACTERIZATION OF OXADIAZOLE DERIVATIVES FROM BENZIMIDAZOLE

 

(Sintesis dan Perincian Terbitan Oksadiazol Dari Benzimidazol)

 

Norizan Ahmat^{1, 2}*, Nik Khairunissa Nik Abdullah Zawawi^1,2, Muhammad Taha^1,2, Nor Hadiani Ismail^1,2, Noraishah Abdullah¹

 

¹Faculty of Applied Sciences,

Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

²Atta-ur-Rahman Institute for Natural Product Discovery,

Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia  

 

*Corresponding author: noriz118@salam.uitm.edu.my

 

 

Received: 24 February 2015; Accepted: 27 October 2015

 

 

Abstract

Heterocyclic compounds of benzimidazole and oxadiazole are considered as important class of compounds in medicinal chemistry because of their interesting diversified biological activities. A series of new benzimidazole bearing oxadiazole derivatives have been conveniently synthesized by intermolecular oxidative cyclization of benzimidazole benzoyl hydrazide promoted by iodobenzene diacetate as an oxidant. The structures of the synthesized compounds were characterized by spectroscopic methods namely ¹H Nuclear Magnetic Resonance (NMR), Infrared (IR), Mass Spectrometry (MS) and melting point.

 

Keywords:  synthesis, benzimidazole, oxadiazole, hydrazide, nuclear magnetic resonance

 

Abstrak

Sebatian heterosiklik daripada benzimidazol dan oksadiazol dianggap sebagai satu kelas sebatian penting dalam kimia perubatan kerana aktiviti biologinya yang pelbagai. Satu siri baru terbitan oksadiazol dari benzimidazol telah disintesis dengan mudah oleh siklisasi oksidatif antara molekul daripada benzoil hidrazida benzimidazol dimangkin oleh diasetat iodobenzena sebagai oksidan. Struktur sebatian disintesis telah dicirikan oleh kaedah spektroskopik seperti ¹H Resonans Magnet Nukleus (NMR), Inframerah (IR), Spektrometri Jisim (MS) dan takat lebur.

 

Kata kunci:  sintesis, benzimidazol, oxadiazol, hidrazida, resonan megnetik nukleus

 

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