Endometriosis

About

The Endometriosis Research Team is dedicated to unraveling the complexities of endometriosis, a chronic and often debilitating condition affecting millions of individuals worldwide. Our team aims to understand the underlying causes, diagnostic challenges, and therapeutic options for endometriosis. By integrating advanced technologies such as genomics, proteomics, and imaging, we aim to uncover novel biomarkers and develop more effective, personalized treatments. Our mission is to improve the quality of life for those affected by endometriosis through groundbreaking research, education, and advocacy.

Research Unit Members

Profesor Madya Dr. Abdul Kadir Abdul Karim

Dr. Nor Haslinda Abd Aziz

Profesor Dr. Mohamad Nasir Shafiee

Profesor Madya Dr. Mohd Faizal Ahmad

Selected Research Projects

1. Uncovering the role of progesterone resistance in the different responses towards medical therapy in endometriosis patients (Geran Kebangsaan)
2. Characterization of peritoneal macrophages from the eutopic and ectopic endometrial tissues of women with and without endometriosis (Geran Universiti)
3. Elucidating the Effect of Progesterone Resistance in the Pathogenesis of Endometriosis (Geran Fakulti)
4. Differential Cytokines and Growth Factors Genes Expression between Women with and without Endometriosis (Geran Fakulti)
5. The Effect of Dienogest on Serum CA-125, Interleukin-6 and P53 Protein among Patient with Endometriosis : Proof of Concept Study (Geran Fakulti)
6. Effects of co-treatment with aromatase inhibitor or progestin on endometrial αvβ3-integrin expressions in women with recurrent implantation failure (Geran Universiti)
7. Changes in Progesterone Receptors Isoform Causing Progesterone Resistance in Endometriosis (Geran Universiti)

Selected Research Publications

1. Progesterone receptor isoform expression in endometriosis in Malaysian population. Medicine & Health, Vol. 13, halaman 172. http://doi.org/10.17576/MH.2018.s1302
2. Identifying signature molecular biomarkers in endometrioid and clear cell ovarian carcinoma with underlying endometriosis. Medical Journal of Malaysia, jilid 74, halaman 44. http://www.e-mjm.org/2019/v74s1/GY-39-40.pdf
3. Perturbations in progesterone receptor isoforms in endometriosis. Journal of Reproductive Medicine, jilid 64, halaman 275-281 http://www.reproductivemedicine.com/toc/auto_toc.php?month=August&year=2019
4. The effect of surgical intervention of endometriosis to ca-125 and pain. Malaysian Journal of Medical Science, jilid 27, halaman 7-14. https://doi.org/10.21315/mjms2020.27.6.2
5. Expression of HOXA10 gene in women with endometriosis: A systematic review
   International Journal of Molecular Sciences, jilid 24, halaman 1 – 14

https://doi.org/10.3390/ijms241612869

6. Expression of HOXA10 in endometriotic women following modulation of gonadotropin-releasing hormone receptor. Medical Journal of Malaysia, jilid 78, halaman 84. https://www.e-mjm.org/2023/v78s1/index.html
7. HOXA10 DNA methylation level in the endometrium women with endometriosis: A systematic review. Biology, jilid 12, halaman 1 – 11. https://doi.org/10.3390/biology12030474
8. PTEN and PI3K mutation markers and expression of cd68 and il-6 inflammatory markers in endometrioid and clear cell ovarian carcinoma with underlying endometriosis. Medicine and Health, jilid 19, halaman 257 – 270. https://doi.org/10.17576/MH.2024.1901.18