Endometrial Cancer Research Group

About

The Endometrial Cancer Research Group is interested in discovering and validating putative biomarkers for the early detection and prediction of various endometrial cancer outcomes. We are currently working on a considerable amount of research projects, aiming to provide the shreds of pre-clinical evidence for changes that may translate into clinical practice. Our research focused on a wide range of common gynaecological issues and targeted signaling pathways, contributing to a better knowledge of endometrial cancer prevention, diagnosis and management. The research group has also emphasized the overall well-being of endometrial cancer’s women impacted by gynaecological issues and fertility, and the quality of life factors that arise as a consequence of these conditions. As part of the drive to promote women’s health, we sought to develop tools that would aid women experiencing these sorts of challenges, as well as several public health initiatives for women to encourage endometrial cancer screening in our community.

 Research Unit Members

Profesor Dr. Mohamad Nasir Shafiee

Profesor Madya Dr. Chew Kah Teik

Profesor Dr. Nirmala @ Chandralega A/P Kampan

Dr. Nor Haslinda Abd Aziz

Selected Research Projects

1. Correlation between PTEN, KRAS, IGF-1 and IGFBP-1 in women with endometrioid adenocarcinoma (FRGS)
2. Waist to hip ratio and or HOMA-IR index as a predictive tool for IGF-1 mediated insulin resistance in type 1 endometrial cancer (Geran Fakulti)
3. Immunoprofiling of PD-1 signalling pathway among women among with endometrial cancer (FRGS)
4. Elucidating the role of IGF-1 Isoforms in Endometrioid Endometrial Cancer Microenvironment and Its Association with Clinical Outcomes (FRGS).
5. Investigating Microbiome Profile in Endometrioid Endometrial Cancer (Geran Fakulti).

6. A Cross-Sectional Study of the Prognostic Significance of PTEN Protein in Endometrioid Endometrial Adenocarcinoma (Geran Fakulti).
7. A Cross-Sectional Study on the Association of Metabolic Syndrome and its Constituent Factors with Endometrial Carcinoma Subtypes at UKMMC (Geran Fakulti).
8. Endometrial Gene Expression In PCOS Women Following Metformin Therapy In Prevention Of Endometrial Cancer (Geran Fakulti).

Selected Research Publications

1. Lipidomic biomarkers in polycystic ovary syndrome and endometrial cancer International Journal of Molecular Sciences, jilid 21, halaman 1-15. https://doi.org/10.3390/ijms21134753
2. PD-L1 expression in endometrial cancer and its association with clinicopathological features: A systematic review and meta-analysis. Cancers, jilid 14, halaman 1-18. https://doi.org/10.3390/cancers14163911
3. Efficacy and safety of PD-1/PD-L1 inhibitor as single-agent immunotherapy in endometrial cancer: A systematic review and meta-analysis. Cancers, jilid 15, halaman 1 – 18. https://doi.org/10.3390/cancers15164032
4. Expression of PD-1 and PD-L1 in endometrial cancer: Molecular and clinical significance
   International Journal of Molecular Sciences, jilid 24, 1 – 17. https://doi.org/10.3390/ijms242015233
5. Sexual Dysfunction among Gynaecological Cancer Survivors: A Descriptive Cross-Sectional Study in Malaysia. International Journal of Environmental Research and Public Health, jilid 14, halaman 15545. https://doi.org/10.3390/ijerph192315545​
6. A Rare Presentation of Endometrial Cancer Recurrence with Scapular metastasis: A Case Report and Review of the Literature. The Annals of African Surgery, jilid 19, halaman 125-129. https://doi.org/10.4314/aas.v19i2.11.
7. Distant recurrence of endometrial cancer more than 10 years after hysterectomy: a case report. Journal of the Egyptian National Cancer, jilid 32, halaman 41. https://doi.org/10.1186/s43046-020-00044-1
8. Preventing endometrial cancer risk in polycystic ovarian syndrome (PCOS) women: could metformin help? Gynecologic Oncology. Jilid 132, halaman 248-253. https://doi.org/10.1016/j.ygyno.2013.10.028