RESEARCH INTERESTS

 MySepsis group was found in 2013 as an initiative to provide continuous education and updates on the management of sepsis to Malaysian healthcare professionals. The MySepsis group consists of a multidisciplinary team which includes clinicians, scientists and researchers from the Faculty of Medicine, Faculty of Engineering and School of Chemistry of UKM. We are also actively involved in fundamental research of sepsis pathology, with the aim to translate laboratory findings to better bedside diagnostics and management. Our team members are actively involved in research on sepsis biomarkers, antimicrobial resistance and POCT (point of care test) development. Using a transdisciplinary approach, we are currently developing a rapid, portable sepsis diagnosis kit to be used beyond the emergency department and primary healthcare setting e.g. in natural disasters and war-afflicted regions where sepsis readily occurs but is challenging to diagnose and treat. The idea for this sepsis diagnosis kit has been filed for patent and its prototype is currently being developed. MySepsis is committed to provide the best evidence-based care to sepsis patients. Our group aim to provide insights in identifying sepsis and highlight the burden of this disease. Looking at recent epidemics and pandemics around the world, it is critical that healthcare professionals are familiar in dealing with infectious disease outbreaks. The path of sepsis evolution is built on discussion in dilemmas while treating sepsis and the reintroduction of a systematic approach in managing sepsis. “Sepsis Evolution: Recognize. Rectify”.

MEMBERS OF RESEARCH GROUP

We are looking for Postgraduate Master or PhD Students and Post-doctoral fellow who are highly motivated and who are curious to know more about Sepsis. If you are interested to join our team, please contact:

Name: Assoc. Prof. Dr. Tan Toh Leong (Group leader)

Email: sebastianttl@yahoo.co.uk

PUBLICATIONS

1. “CD64 and group II secretory phospholipase A2 (sPLA2-IIA) as biomarkers for distinguishing adult sepsis and bacterial infections in the emergency department. TL Tan, NS Ahmad, DN Nasuruddin, A Ithnin, K Tajul Arifin, IZ Zaini. PLoS One 11 (3), e0152065”
2. “An Amperometric Biosensor for the Determination of Bacterial Sepsis Biomarker, Secretory Phospholipase Group 2-IIA Using a Tri-Enzyme System. NN Nik Mansor, TL Tan, E Safitri, D Futra, NS Ahmad, DN Nasuruddin. Sensors 18 (3), 686”
3. “The role of group IIA secretory phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults—A systematic reviewTL Tan, YY Goh. PloS one 12 (7), e0180554”
4. “Pulsed-field gel electrophoresis (PFGE): A review of the “gold standard” for bacteria typing and current alternatives. H Neoh, XE Tan, HF Sapri, TL Tan. Infection, Genetics and Evolution 74, 103935”
5. “Comparison of Prognostic Accuracy of the quick Sepsis-Related Organ Failure Assessment (qSOFA) between Short- & Long-term Mortality in Patients Presenting Outside of the ICU Setting. TL Tan, YJ Tang, LJ Ching, N Abdullah, HM Neoh. Scientific Reports 8, 16698”
6. “Antimicrobial resistance profiling and molecular typing of methicillin-resistant Staphylococcus aureus isolated from a Malaysian teaching hospitalA Noordin, HF Sapri, NAM Sani, SK Leong, XE Tan, TL Tan, NM Zin. Journal of Medical microbiology 65 (12), 1476-1481”
7. “The 28-Day Mortality Prediction in Sepsis Patients Using Static Lactate Concentration and Early Lactate Clearance: An Observational StudyToh Leong Tan, Noor Asmidar, Wei Jie Ong, Ahmad Fuad Fahmi, Zhin Liang. Medicine & Health Journal 9 (2), 124-133”
8. “Comparative proteomics profiling reveals down-regulation of Staphylococcus aureus virulence in achieving intermediate vancomycin resistanceX Tan, H Neoh, M Loo, TL Tan, S Hussin, L Cui, K Hiramatsu, R Jamal. Malaysian Journal of Microbiology 12 (6), 498-505”
9. “Advantages and Limitations of 16S rRNA Next-Generation Sequencing for Pathogen Identification in the Diagnostic Microbiology Laboratory: Perspectives from a Middle-Income Country. NS Muhamad Rizal, H Neoh, R Ramli, A Hanafiah, MN Abdul Samat. Diagnostics 10 (10), 816”
10. “Molecular surveillance of methicillin-susceptible Staphylococcus aureus (MSSA) isolated over a one-year period from a Malaysian Teaching HospitalHF Sapri, MAH Ismail, NAM Sani, A Noordin, TL Tan, S Hussin, H Neoh. Germs 10 (2), 104”
11. “High sPLA2-IIA level is associated with eicosanoid metabolism in patients with bacterial sepsis syndromeNS Ahmad, TL Tan, KT Arifin, WZW Ngah, YAM Yusof. PloS one 15 (3), e0230285”
12. “Sepsis Management: A Quick Guide. TL Tan, JY Lim. Malaysian Sepsis Alliance”
13. “Rapid Detection of Sepsis using CESDA: The Caenorhabditis elegans Sepsis Detection Assay.LF Tee, TL Tan, H Neoh, R Jamal. Revista da Sociedade Brasileira de Medicina Tropical 52”
14. “Sepsis: The New Insight. TL Tan, NH Ahmad, HM Neoh. ISBN 9789674127398 1,1-64”
15. Kaku Y, Park ES, Noguchi A, Inoue S, Lunt R, Malbas FF Jr, Demetria C, Neoh HM, Jamal R, Morikawa S. Establishment of an immunofluorescence assay to detect IgM antibodies to Nipah virus using HeLa cells expressing recombinant nucleoprotein. J Virol Methods. 2019 Apr 5; 269:83-87.