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Sains Malaysiana 47(11)(2018): 27052711 http://dx.doi.org/10.17576/jsm-2018-4711-14
Malaysian Tualang Honey and Its Potential Anti-Cancer Properties: A Review (Madu Tualang Malaysia dan Potensi Sifat Anti-Kansernya: Suatu Kajian) AHMAD FIRDAUS
BIN KHALID1, JUN
JIE
TAN2
& YOKE KEONG YONG1*
1Department of Human
Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra
Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia 2Advanced Medical and
Dental Institute, Universiti Sains Malaysia, Bertam, 13200 Kepala
Batas, Pulau Pinang, Malaysia Received: 8 March 2018/Accepted:
30 July 2018 ABSTRACT The use of honey as a therapeutic
agent dates back at 8000 years and has markedly increased interest
into its potential health benefits. The by-products of the flower
nectar have a complex chemical composition which promotes benefits
in underlying mechanism of human diseases. Malaysian Tualang Honey
(MTH) is a multifloral jungle honey produced by the rock
bee (Apis dorsata). This review consolidates the results
of carious studies involving biochemical assays of tissue culture
and animal trials of anti-cancer properties of MTH. Often studied in the context of
breast cancer cell lines, MTH has promising data for possible
mechanisms in anti-cancer activity. These include apoptosis via
depolarization of the mitochondrial membrane, caspase-dependent
apoptosis, reduction of angiogenesis and the promotion of cell
cycle arrest without posing cytotoxic effect on normal cell lines.
Despite positive outcomes in tissue cultures, the oral administration
of MTH in breast cancer animal models showed
slower tumour progression, reduction in tumour size and better
grading of histological features. The alleviation of breast carcinogenesis
via modulation of hematologic, estrogenic and apoptotic activities
promotes MTH
as a promising anticancer agent. With confidence
in a conclusion that MTH
is a useful treatment for cancer, further experimental
and clinical studies should be conducted. Keywords: Anti-cancer; anti-proliferative;
breast cancer; Malaysian Tualang Honey ABSTRAK Penggunaan madu sejak 8000
tahun yang lalu sebagai agen terapeutik telah meningkat dengan
ketara kerana potensi manfaatnya kepada kesihatan. Produk sampingan
daripada nektar bunga ini mempunyai komposisi kimia yang kompleks
dan menpromosikan manfaat untuk mengubati penyakit manusia pada
peringkat asas mekanisme penyakit tersebut. Madu Tualang Malaysia
(MTH) adalah madu hutan pelbagai jenis
flora yang dihasilkan oleh lebah Tualang, lebah madu gergasi atau
dikenali sebagai naning (Apis dorsata). Kertas ini melaporkan keputusan pelbagai
kajian yang melibatkan ujian biokimia untuk menguji sifat anti-kanser
MTH
yang dijalankan terhadap kultur tisu dan model haiwan.
Kajian yang dijalankan ke atas sel selanjar kanser payudara menunjukkan
bahawa MTF mempunyai
aktiviti anti-kanser. Perkara ini termasuklah apoptosis melalui
depolarisasi membran mitokondria, apoptosis bersandarkan-caspase,
pengurangan angiogenesis dan pemberhentian kitaran sel tanpa mempunyai
kesan sitotoksik terhadap sel selanjar normal. Walaupun kesan
positif MTF terhadap kultur sel, pemberian
MTH secara oral kepada model kanser payudara haiwan menunjukkan
bahawa MTH memperlahankan perkembangan tumor,
mengurangkan saiz tumor dan membaiki gred histologi sel tumor.
Kesan MTH
terhadap pengurangan karsinogenesis payudara melalui
modulasi aktiviti hematologi, estrogen dan apoptosis memungkinkan
MTH menjadi agen anti-kanser yang berpotensi.
Untuk memperoleh keputusan yang lebih meyakinkan bahawa MTH
boleh menjadi rawatan yang berguna untuk kanser,
uji kaji lanjutan dan kajian klinikal perlu dilakukan. Kata kunci: Anti-kanser;
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