The Malaysian Journal of Analytical Sciences Vol 12 No 2 (2008): 491 – 499

 

 

 

Development of controlled drug release formulation based on pamoate-zinc-aluminium-layered double hydroxide nanocomposite

 

Zaemah bt Jubri¹,  Mohd Zobir bin Hussein², Asmah Hj Yahaya²,

Zulkarnain Zainal², Siti Halimah Sarijo²

 

¹Department of Engineering Sciences and Mathematics, College of Engineering,

 Universiti Tenaga Nasional,

43009 Kajang, Selangor, Malaysia.

²Nanomaterial Programme, Advanced Material Laboratory,

Institute of Advanced Technology (ITMA),

UPM, 43400, Serdang, Selangor, Malaysia

 

Abstract

Controlled drug release formulation of pamoate was developed by the intercalation of pamoate anion into Zn-Al-layered double hydroxide (LDH). The resulting layered organic-inorganic hybrid nanocomposite material was formed using pamoate as guest anion intercalated into the Zn-Al layered double hydroxide inorganic host by direct co-precipitation method. As a result of successful intercalation of pamoate ion into the interlayer structure of Zn-Al-LDH, an expansion of the interlayer spacing, from 8.9 Å in the layered double hydroxide to 18.1 Å in the nanocomposite (ZAP) could be observed in the powder X-ray diffractogram. The reverse process, i.e., the deintercalation or release of the guest, pamoate was found to be rapid initially, followed by a more sustained release thereafter and this behavior was dependent on the pH of the release medium, the aqueous solution. The mechanism of release has been interpreted on the basis of the ion-exchange process between the pamoate anion intercalated in the lamella host and nitrate, or hydroxyl anions in the aqueous solution. This study suggest that layered double hydroxide can be used as a carrier for drugs that allow safe and controlled delivery of various bioagents into target with high efficiency.

 

Keywords: controlled release, pamoate anion, layered double hydroxide, organic-inorganic hybrid

 

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