Malaysian Journal of Analytical Sciences Vol 19 No 2 (2015): 445 – 453

EFFECT OF PH BUFFER ON SELF-HEALING HYDROGEL

(Kesan Penggunaan Larutan Penimbal pH Terhadap Swa Pemulihan Hidrogel)

Najiyyah Abdullah Sirajuddin, Mohd Suzeren Md Jamil*, Mohamad Azwani Shah Mat Lazim

School of Chemical Sciences and Food Technology,

Faculty Science & Technology,

Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia

*Corresponding author: suzeren@ukm.edu.my

Received: 8 December 2014; Accepted: 14 January 2015

Abstract

Autonomous healing of damage is a common phenomenon in living organisms but is hardly ever encountered in synthetic materials. Disulﬁde chemistry is used to introduce a self-healing ability in a covalently cross-linked hydrogel. This result is achieved by introducing disulﬁde groups in the network that are able to exchange, leading to renewal of cross-links across the damaged surfaces. ATR results showed that C=C had disappeared once the gel was formed and the percentage of gel fraction is 86%. The gel being cut shows highest healing efficiency in borax-sodium hydroxide buffer (pH 10) which is 95%. The combination of this unique self-healing properties and applicability for a large variety of polymers makes this approach ideal for biomedical applications.

Keywords : disulfide bond, basic medium, self-healing hydrogel

Abstrak

Pemulihan autonomik ke atas sebarang kerosakan atau kecederaan merupakan suatu fenomena yang berlaku pada organisma hidup tetapi sukar untuk diaplikasikan pada bahan sintetik. Keupayaan swa pemulihan dapat dicapai dengan menggunakan ikatan kovalen dinamik iaitu ikatan disulfida ke dalam suatu jaringan polimer. Ini kerana ikatan disulfida berupaya untuk putus dan cantum sekaligus dapat membawa kepada pembentukan semula taut silang pada permukaan yang terjejas. Hasil daripada ATR menunjukkan puncak C=C pada monomer telah hilang apabila gel sudah terbentuk dan peratusan keberhasilan gel adalah sebanyak 86%. Keberkesanan pemulihan paling tinggi adalah pada gel yang telah direndam dalam larutan penimbal borax-natrium hidrosida (pH 10) iaitu sebanyak 95%. Gabungan uniq antara ciri-ciri swa pemulihan dan kebolehupayaan tinggi dalam swa pemulihan menjadikan hidrogel ini amat sesuai untuk digunakan dalam aplikasi bioperubatan.

Kata kunci: Ikatan disulfida, medium alkali, swa pemulihan hidrogel

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