Malaysian
Journal of Analytical Sciences Vol 19 No 4 (2015): 799 - 807
GLUCOSE SULFATE IMPRINTED POLYMER PREPARED BY
SOL-GEL PROCESS ON SILICA MICROPARTICLES SURFACE: KINETIC MODELING AND ISOTHERM
STUDIES
(Penyediaan Glukosa Sulfat Polimer Tercetak Melalui
Proses Sol-Gel Pada Permukaan Mikro Zarah Silika: Kajian Model Kinetik dan
Isoterma)
Azalina Mohamed Nasir1*, Mohd Noor Ahmad1, Mohd
Irfan Hatim Mohamed Dzahir2, Noorhidayah Ishak1
1School of Material Engineering,
Universiti
Malaysia Perlis,
Kompleks Pusat
Pengajian Jejawi II, Taman Muhibah, 02600 Arau, Perlis, Malaysia
2School of Bioprocess Engineering,
Universiti
Malaysia Perlis,
Pusat Pengajian
Jejawi III, 02600 Arau, Perlis, Malaysia
*Corresponding author: azzalina80@gmail.com
Received:
23 November 2014; Accepted: 27 June 2015
Abstract
Determination
of monomers or structures of Glucose sulfate (sulfated sugars) are prerequisite
for understanding their biological roles. Here, surface molecular imprinted
polymer (MIP) on silica gel particles was applied for recognition of the
biologically relevant sulfated sugar substitution on sugar. The non-covalent
surface MIP was prepared by a sol-gel process using three different functional
monomers; amine, imidazole and methyl-imidazole functioned silane with glucose
sulfate as template model. The sulfated sugar imprinted silica microparticles
were characterized by Fourier Transform Infrared Spectroscopy (FT-IR). A batch
adsorption experiment were carried out at constant temperature between these
MIPs of three different monomers and shown that all MIPs presented the best fit
to Langmuir isotherm model. The MIP-methyl-imidazole had showed highest binding
capacity of 53.07 mg/g, whereas the MIP-amine possess high imprinting factor
(IF; 2.24). Nevertheless, MIP with high imprinting factor was preferred due to
the high affinity and more specific interaction of the template adsorption. The kinetic model behavior study was carried out on
these MIPs. The results indicated that the MIP-amine and MIP-imidazole were
best described of pseudo-second-order kinetic model while, the
MIP-methyl-imidazole can be expressed as pseudo-first order kinetic model.
Keywords: glucose
sulfate, kinetic modeling and isotherm, molecular imprinted polymer, sol-gel
process
Abstrak
Penentuan
monomer atau struktur glukosa sulfat (gula sulfat) adalah pra-syarat untuk
memahami peranan biologinya. Di sini, permukaan polimer molekul tercetak (MIP)
pada zarah silika gel telah digunakan bagi mengenalpasti sifat biologi yang
berkaitan dengan penggantian gula sulfat pada gula. Permukaan MIP bukan kovalen
telah disediakan melalui proses sol-gel menggunakan tiga monomer fungsian yang
berbeza; amina, imidazole dan metil-imidazole berfungsi silana dengan sulfat
glukosa sebagai model templat. Gula sulfat tercetak pada silika zarah mikro
telah dikenalpasti oleh Spektrofotometer Inframerah Transformasi Fourier
(FT-IR). Satu kumpulan eksperimen penjerapan telah dijalankan pada suhu malar
di antara MIP yang mempunyai tiga jenis monomer berbeza dan ini menunjukkan
bahawa kesemua MIPs menunjukkan ianya sesuai kepada Langmuir model isoterma. The MIP-metil-imidazole telah menunjukan kapasiti
ikatan tertinggi 53.07 mg/g, manakala MIP-amina mempunyai faktor tercetak
tinggi (IF; 2.24). Walau bagaimanapun, MIP dengan faktor tercetak tertinggi
telah dipilih disebabkan oleh afiniti yang tinggi dan interaksi yang lebih
khusus bagi penjerapan template. Kajian terhadap tingkah laku model kinetik
telah dijalankan ke atas MIP ini. Keputusan menunjukkan bahawa MIP-amina dan
MIP-imidazole telah mengikuti model kinetik pseudo-tertib kedua sementara, yang
MIP-metil-imidazole boleh dinyatakan sebagai model kinetik pseudo-pertama.
Kata kunci: gula sulfat,
model kinetik dan isoterma, permukaan polimer molekul tercetak, proses sol-gel
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