Sains Malaysiana 37(4): 395-399 (2008)
Fabrication of Porous Hydroxyapatite for Bone Graft
Substitutes via Gas Technique
(Fabrikasi Hidroksiapatit Poros Melalui Teknik
Gas
sebagai Tulang Geraf Gantian)
Mohd
Reusmaazran Yusof
& Idris Besar
Malaysian
Nuclear Agency
Bangi,
43000 Kajang, Selangor D. E. Malaysia
Roslinda
Shamsudin & Syafiq
Baharuddin
School
of Applied Physics, Faculty of Science and Technology
Universiti
Kebangsaan Malaysia
43600
UKM Bangi, Selangor D. E. Malaysia
Received : 2 October 2007 / Accepted :
22 February 2008
ABSTRACT
Porous hydroxyapatite
(HAp) as a bone graft substitute was
produced via gas technique with three different concentrations
of hydrogen peroxide (H2O2) namely 20,
30 and 50%. Hydroxyapatite(HA) slurries with different concentration were produced by
mixing between H2O2 solutions and HA powder
(L/P) with different ratio i.e. 0.9 to 2.20 ml.g-1.
Different L/P ratio and H2O2 concentration
affected the porosity, interconnectivity and compressive strength
of HAp sample. Changes in L/P ratio
between 0.9 to 2.20 ml.g-1, increases the porosity
around 50 - 65% at 20% H2O2 concentration.
Porosity increases with the L/P values and H2O2
concentration which 76% of porosity was obtained at 50% H2O2
and 2.20 mlg-1 of L/P. The compressive strength
of HAp is in the range of 0.5 to 2.15
MPa and is found decreasing with the
increasing of L/P values.
Keywords: Compressive strength; interconnectivity; porous
hydroxyapatite; porosity
ABSTRAK
Hidroksiapatit
poros (HAp)
sebagai tulang geraf gantian sintetik
dihasilkan melalui teknik gas dengan
menggunakan gas hidrogen peroksida (H2O2)
pada kepekatan 20, 30 dan 50%. Buburan hidroksiapatit(HA)
dihasilkan daripada
nisbah larutan H2O2 terhadap serbuk HA
(L/P) antara 0.9 hingga 2.20 mlg-1 bagi
memperolehi kelikatan
buburan yang berlainan. Kepekatan
larutan H2O2 dan nisbah L/P yang berbeza
mempengaruhi keporosan,
keterjalinan hubung antara liang dan kekuatan
mampatan sampel HAp. Perubahan L/P antara 0.9 hingga 2.20 mlg-1
telah meningkatkan
keporosan sebanyak 50 - 65% pada
20% kepekatan larutan H2O2. Keporosan
meningkat dengan
nilai L/P dan kepekatan
larutan H2O2 dimana 76% keporosan
dicapai pada kepekatan
50% larutan H2O2 dan L/P sekitar 2.20
mlg-1. Kekuatan mampatan HAp adalah antara 0.5 hingga 2.15 MPa dan didapati menurun dengan peningkatan
nisbah L/P.
Kata kunci: Hidroksiapatit
poros; kekuatan mampatan;
keporosan; kerterjalinan hubung
REFERENCES/RUJUKAN
Bignon, A., Chouteau, J., Chevalier, J.,Fantozzi, G. Carret. J.P., Chavassieux, P. Boivin,
G., Melin, M. & Hartmann, D. 2003. Effect of micro and macroporosity
of bone substitutes n their mechanical properties and cellular
response. Materials Science: Material in Medicine 14:
1089-1097
Hing, K. A., Best,
S. M. & Bonfield, W. 1999 Characterization
of porous hydroxypapatite.
Materials Science: Material in Medicine 10:
135-145.
Melynykowycz, J
& Carotenuto, C. 2000.
Mechanical characterization of porous hydroxyapatite
scaffold. J. of
Biomedical Research 46: 73-80.
Reusmaazran M.
Y., Idris B., Rusnah
M. and Rohaida C. H. 2004.
HAp physical investigation.
Malaysian Med. J. 59: 79-80.
Rivera, M., E., Diaz, J. R., Rodriguez, J. R. Brostow,
W. & Castano V. M. 2001.
Hydroxyapatite spheres with controlles
porosity for eye ball prosthesis: processing and characterization.
Materials Science: Material in Medicine 12:
305-311.
Ryu, H. S., Kim,
S. J., Kim, J. H., Kim H. and Hong K. S. 2004. Fabrication
of 1-dimensional porous hydroxyapatite
and evaluation of its osteoconductivity
2004. Materials Science: Material in Medicine 15:
276-273.
Tampieri, A., Celotti,
G., Szontagh, F. & Landi
E. 1997. Sintering and characterization
of HA and TCP bioceramics with control of their strength and phase purity.
Materials Science: Material
in Medicine 8: 29-37.
Wan K, Roslinda S., & Daud A.R. D. 2005. Injectable hydroxyapatite
- β-tricalcium phosphate-calcium
phosphate biocement. Sains Malaysiana 34(2): 67-70.
Yang, H. Y. & Wang, M. 1999. Investigation into manufacture
of porous hydroxyapatite via three
different route. Proceedings of the 12th International
Syimposium on Ceramics in Medicine.
pp 349-352.
Yoshio, O., Tashiro,
K. & Yoshiro A. 1997. Preparation
and compressive strength behavoiur
of porous ceramics with β-Ca(PO3)2
fiber skeletons. Journal
of American Ceramics Society 80(11): 225 231.