Sains
Malaysiana 38(1): 57-59(2009)
Evaluation of Diuretic Potential of Nephrolepis
cordifolia
rhizome Juice in Wistar Rats
(Penilaian Potensi Diuretik Jus Rizom Nefrolepis kordifolia Jus
Rizom Terhadap Tikus Wistar)
A.
Rajasekaran
School of Pharmacy,AIMST University
Bukit Air Nasi, Jalan Bedong Semeling
08100, Bedong, Kedah Darul Aman, Malaysia
Received: 17 March 2008 /
Accepted: 27 May 2008
ABSTRACT
Nephrolepis
cordifolia rhizome (sword fern) juice was investigated for diuretic activity in wistar rats. Different parameters
viz. total urine volume (corrected for water intake during the test period),
urine concentration of electrolytes such as sodium, potassium and chloride have
been evaluated. Rhizome juice of Nephrolepis
cordifolia (100 mg/kg),
the reference drug, furosemide (20 mg/kg) was administrated orally to male
Wistar rats and their urine output was quantitated at several intervals of time
after the dose. After single dose of the rhizome juice of Nephrolepis cordifolia, urine output
was significantly increased. Increase in urinary levels of Na+, K+ and Cl- was also observed after the administration of rhizome juice.
Keywords: Diuretic activity; Nephrolepis
cordifolia; rhizome juice extract
ABSTRAK
Kesan jus rezom Nefrolepis
cordifolia rizom terhadap aktiviti diuretic dalam tikus wistar telah
dikaji. Parameter berlainan iaitu jumlah isipadu kencing (dibetulkan terhadap
pengambilan air semasa ujian) dan kepekatan elektrolit seperti natrium, kalium
dan klorida telah diukur. Jus rizom Nefrolepis
kordifolia (100 mg/kg), dadah rujukan, furosemid (20 mg/kg) telah diberikan
secara oral kepada tikus Wistar jantan dan output kencing telah dikira pada
beberapa sela masa selepas setiap dos. Selepas setiap dos jus rizom Nefrolepis kordifolia output kencing
meningkat dengan ketara. Peningkatan dalam aras Na+, K+ dan Cl- telah dicerap selepas jus rizom diberikan.
Kata kunci: Aktiviti diuretik;
ekstrak jus rizom; Nefrolepis kordifolia
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