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Preparation, Characterization and Properties of Core-Shell Cobalt Ferrite/Polycaprolactone Nanomagnetic Biomaterials (Penyediaan, Pencirian dan
Sifat-sifat Rangka-Teras Nanomagnetik Biobahan Kobalt Ferit/Polikaprolakton)
Khoo Kok Siong*, Nur Farhana Amari, Tan Chun Yuan, Shahidan Radiman,
Redzuwan Yahaya
& Muhamad Samudi Yasir
School of
Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan
Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia
Diserahkan:
8 Mac 2012 / Diterima: 23 Jun 2012
ABSTRACT
Combination of magnetic and
biocompatible materials to form core-shell nanomaterials has been widely used
in medical fields. These core-shell magnetic biomaterials have a great
potential for magnetic fluid hyperthermia (MFH)
treatment to remedy cancer. The aims of this study were to investigate the
production of core-shell cobalt ferrite/polycaprolactone (CoFe2O4/PCL)
nanomaterials with different ratios of cobalt ferrite to caprolactone, to study
the effects of using polymer in reducing the agglomerations between particles
and to determine the structure, morphology, thermal and magnetic properties of
these core-shell nanomaterials. The core-shell nanomaterials were produced by in situ polymerization method. The formation of the CoFe2O4/PCL was
investigated by means of Fourier transform infrared spectroscopy (FTIR),
x-ray diffractometer (XRD) and transmission electron
microscopy (TEM). Its thermal properties were determined by using thermogravimetric
analyzer (TGA). The vibrating sample magnetometer (VSM)
was used to reveal the magnetic properties. The results for the XRD and FTIR spectra demonstrated the formation of cobalt ferrite and
polycaprolactone in core-shell nanomaterials. From the TEM results,
it was seen that the core-shell CoFe2O4/PCL nanomaterials
were best formed at a ratio of CoFe2O4 to
monomer caprolactone mixtures of 1:4.
Keywords: Cobalt ferrite; core-shell
nanomaterials; polycaprolactone; TEM image
ABSTRAK
Gabungan
penggunaan bahan bersifat magnetik dan bioserasi bagi menghasilkan rangka-teras
nanobahan telah digunakan secara meluas dalam bidang perubatan. Rangka teras biobahan magnet ini mempunyai potensi yang besar
sebagai hipertemia cecair magnetik (MFH) bagi merawat barah. Tujuan kajian ini adalah untuk mengkaji penghasilan rangka-teras nanobahan CoFe2O4/PCL dalam
kadar nisbah kobalt ferit dan kaprolakton yang berbeza, mengenal pasti kesan
penggunaan polimer bagi mengurangkan penggumpalan zarah-zarah kobalt ferit dan
melakukan pencirian struktur, morfologi, haba dan magnetik terhadap nanobahan
ini. Rangka-teras nanobahan ini dihasilkan melalui proses pempolimeran in situ. Pembentukannya ditentukan menggunakan
teknik pembelauan sinar-x (XRD), spektrometri transformasi Fourier
inframerah (FTIR) dan mikroskop transmisi elektron (TEM). Sifat haba nanobahan ini dicirikan menggunakan penganalisis
termogravimetri (TGA). Magnetometer
sampel bergetar (VSM) pula digunakan bagi mengetahui
sifat magnet bahan. Hasil daripada XRD dan
spektrum FTIR menunjukkan kehadiran kobalt ferit dan
polikaprolakton dalam sampel rangka-teras nanobahan. Morfologi
daripada imej TEM menunjukkan rangka-teras nanobahan hanya terbentuk
pada nisbah campuran 1:4 kobalt ferit ke kaprolakton.
Kata
kunci: Imej TEM; kobalt ferit; nanobahan rangka-teras;
polikaprolakton
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*Pengarang untuk surat-menyurat; email: khoo@ukm.my
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