Sains Malaysiana 45(7)(2016): 1073–1077
Isolation
and Identification of Metabolites from the Gram-negative Proteobacteria of Burkholderia
cenocepacia and Serratia marcescens
(Pengasingan
dan Pengenalpastian Metabolit daripada Proteobakteria Gram-negatif Burkholderia
cenocepacia dan Serratia marcescens)
ANN-CHEE YAP, KOK-GAN CHAN
& YEUN-MUN CHOO*
Department
of Chemistry, University of Malaya, 50603 Kuala Lumpur, Federal Territory, Malaysia
Diserahkan:
30 Jun 2015/Diterima: 11 Februari 2016
ABSTRACT
Burkholderia cenocepacia and Serratia marcescens are
Gram-negative proteobacteria commonly found in the natural environment and are
also opportunistic pathogens that caused a number of human diseases. The
fermentation culture of Burkholderia cenocepacia yielded three
compounds, 4-(2-hydroxyethoxy)-phenol (1), Maculosin (2) and
methyl myristate (3). Compound 2 was also isolated together with cyclo(L-Leu-L-Pro) (4) from Serratia marcescens.
Compound 1 was isolated from a natural source for the first time and the
first isolation of compounds 2-4 was also reported from both Burkholderia
cenocepacia and Serratia marcescens.
Keywords: Burkholderia
cenocepacia; Malaysia microorganism natural products; proteobacteria
metabolites; Serratia marcescens
ABSTRAK
Burkholderia cenocepacia dan Serratia
marcescens adalah proteobakteria Gram-negatif yang biasa dijumpai di alam
semula jadi dan juga patogen yang boleh membawa penyakit kepada manusia. Tiga metabolit telah diasingkan daripada kultur
fermentasi Burkholderia cenocepacia,
iaitu 4-(2-hidroksietoksi)-fenol (1), Maculosin (2) dan metil
miristat (3). Sebatian 2 juga diasingkan bersama siklo(L-Leu-L-Pro) (4) daripada Serratia
marcescens. Sebatian 1 diasingkan untuk pertama kali daripada sumber
hasil semula jadi dan pengasingan untuk sebatian 2-4 juga
dilaporkan buat pertama kali daripada Burkholderia cenocepacia dan Serratia
marcescens.
Kata kunci: Burkholderia cenocepacia; metabolit proteobakteria; sebatian semula
jadi mikroorganisme Malaysia; Serratia marcescens
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*Pengarang
untuk surat-menyurat; email: ymchoo@um.edu.my
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