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Sains Malaysiana 46(10)(2017): 1859–1863
http://dx.doi.org/10.17576/jsm-2017-4610-24
Anti-nociceptive Effect of Caralluma edulis on Peripheral and Central Pain Pathways
(Kesan Anti-nosiseptik Caralluma edulis terhadap Sistem Sakit Berpusat dan Periferal)
SUNDAS FIRDOOS1,
ARIF-ULLAH KHAN1* & FAWAD ALI1,2
1Department
of Basic Medical Sciences, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan
2Department of Pharmacy, Kohat University of Science and Technology, Kohat,
Pakistan
Diserahkan: 7 Mei
2016/Diterima: 29 Mac 2017
ABSTRACT
The purpose of the
present research was to evaluate the phytochemical content and analgesic effect
of Caralluma edulis (Ce.Cr). Established methods
were used for phytochemical analysis of plant. The anti-nociceptic activity of Ce.Cr was scrutinized using acetic
acid-induced writhings, tail immersion and hot plate
methods. Ce.Cr was tested positive for the presence
of therapeutically active metabolites such as alkaloids, flavonoids,
glycosides, phenol, tannins, terpenoids and saponins. Ce.Cr at the dose of
10, 30 and 100 mg/kg inhibited acetic acid-induced abdominal writhes and
increase the latency time to thermal stimuli in both tail immersion and hot
plate tests, similar to standard drug. These results showed that the ethanolic extract of Caralluma edulis possesses anti-nociceptive property.
Keywords:
Anti-nociceptive; Asclepiadaceae; Caralluma edulis
ABSTRAK
Penyelidikan ini bertujuan untuk menilai kandungan fitokimia dan kesan analgesik Caralluma edulis (Ce.Cr). Kaedah sedia ada digunakan untuk menganalisis fitokimia tumbuhan. Aktiviti anti-nosiseptik Ce.Cr diteliti dengan menggunakan kaedah asid asetik bergelut, rendaman hujung dan plat panas. Ce.Cr diuji positif untuk kehadiran metabolit terapeutik aktif seperti alkaloid, flavonoid, glikosida, fenol, tanin, terpenoid dan saponin. Ce.Cr pada dos 10, 30 dan 100 mg/kg merencat abdomen bergelut teraruh asid asetik dan meningkatkan masa kependaman untuk rangsangan terma dalam ujian rendaman hujung dan plat panas seperti piawai dadah. Keputusan ini menunjukkan bahawa ekstrak etanol Caralluma edulis memiliki sifat anti-nosiseptif.
Kata kunci: Caralluma edulis; Asclepiadaceae; Anti-nosiseptif
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*Pengarang untuk surat-menyurat;
email: arif.ullah@riphah.edu.pk
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