Sains Malaysiana 46(2)(2017):
245–254
http://dx.doi.org/10.17576/jsm-2017-4602-09
Mood, Cognitive Function and Quality
of Life Improvements in Middle Aged Women Following Supplementation
with Polygonum minus Extract
(Penambahbaikan Mood dan Kualiti
Kehidupan dalam Kalangan Wanita Pertengahan
Umur Selepas Pemberian Ekstrak Polygonum
minus)
HANIS MASTURA
YAHYA1*,
SUZANA
SHAHAR2,
SITI
NUR
ARINA
ISMAIL1,
AINOR
FARAHIN
AZIZ1,
NORMAH
CHE
DIN3
& BIBI NABIHAH ABDUL
HAKIM2
1Nutritional Sciences
Programme, School of Healthcare Sciences, Faculty of Health Sciences
Universiti Kebangsaan Malaysia,
Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur,
Wilayah Persekutuan, Malaysia
2Dietetics Programme,
School of Healthcare Sciences, Faculty of Health Sciences, Universiti
Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur,
Wilayah Persekutuan
Malaysia
3Health Psychology
Programme, School of Healthcare Sciences, Faculty of Health Sciences
Universiti Kebangsaan
Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Wilayah
Persekutuan, Malaysia
Diserahkan: 4 Disember
2015/Diterima: 8 Jun 2016
ABSTRACT
Polygonum minus is a plant
rich in flavonoids and antioxidants beneficial for reducing oxidative
stress and lipid peroxidation in neuronal membranes. This randomized,
double-blind, placebo-controlled study evaluated the potential
benefits of P. minus extract (LineMinusTM) towards improving cognitive function,
mood status and quality of life. Thirty five middle-aged women
(35-55 years old) were randomized into intervention (n=17)
and control group (n=18). Two capsules of P. minus
(250 mg) or placebo (100 mg maltodextrin) each were taken once
daily for six weeks. Cognitive tests, mood and anthropometric
measurements were measured at baseline, week 3 and week 6, whilst
biomarkers were measured at baseline and week 6. Parameters related
to mood and quality of life including energy/fatigue, social functioning
and general health significantly improved from baseline to week
6 in the intervention group (p<0.05). Mean score for
cognitive tests (i.e. digit span, comprehensive trail making test
(CTMT) and three domains of CNS vital
sign (CNSVS)] improved significantly in both intervention and
control groups (p<0.05). There was a significant decrease
of mean uric acid, estimated glomerular filtration rate (eGFR),
total cholesterol and glycated hemoglobin (HbA1C) in the intervention
group from baseline to week 6. P. minus supplementation
has the potential to improve mood and quality of life and no adverse
effects were reported by the participants after 6 weeks supplementation.
Keywords: Flavonoid; mood;
Polygonum
minus; phytochemicals; quality of life; supplement
ABSTRAK
Polygonum minus adalah tumbuhan
yang kaya dengan flavonoid dan antioksidan serta bermanfaat untuk
mengurangkan tekanan oksidatif dan peroksidasi lipid pada membran
neuron. Kajian ini berbentuk rawak, dwi-buta dan plasebo-terkawal
untuk menilai potensi faedah ekstrak P. minus (LineMinusTM) dalam meningkatkan fungsi
kognitif, status mood dan kualiti hidup. Tiga puluh lima wanita
pertengahan umur (berumur 35-55 tahun) dibahagikan secara rawak
ke dalam kumpulan intervensi (n=17) dan kumpulan kawalan
(n=18). Dua kapsul P. minus (250 mg) atau plasebo
(100 mg maltodekstrin) telah diambil setiap sehari selama enam
minggu. Ujian kognitif, mood dan beberapa ukuran antropometri
telah diukur pada peringkat dasar, minggu 3 dan minggu 6, manakala
penanda biologi diukur pada peringkat dasar dan minggu 6. Parameter
yang berkaitan dengan mood dan kualiti hidup termasuk tenaga/keletihan,
fungsi sosial dan kesihatan meningkat secara signifikan pada peringkat
dasar hingga minggu 6 untuk kumpulan intervensi (p<0.05).
Min skor untuk ujian kognitif seperti Digit Span, Comprehensive
Trail Making Test (CTMT)
dan tiga domain CNS Vital Sign (CNSVS)]
meningkat secara signifikan dalam kedua-dua kumpulan intervensi
dan kawalan (p<0.05). Terdapat penurunan yang signifikan
dalam min asid urik, anggaran kadar penapisan glomerular (EGFR), jumlah kolesterol dan hemoglobin
glycated (HbA1C) dalam kumpulan intervensi pada peringkat dasar
dan minggu 6. Pemberian P. minus mempunyai potensi untuk
memperbaik mood dan kualiti hidup serta tiada kesan buruk dilaporkan
oleh peserta selepas pengambilan selama 6 minggu.
Kata kunci: Fitokimia; flavonoid; kualiti hidup; mood; Polygonum minus;
suplemen
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*Pengarang untuk surat-menyurat; email:
hanis.yahya@ukm.edu.my