Malaysian Journal of Analytical Sciences Vol
19 No 6 (2015): 1171 - 1178
SYNTHESIS,
CHARACTERIZATION AND ANTIBACTERIAL STUDY OF COPPER (II) COMPLEXES OF
THIOSEMICARBAZONES
(Sintesis, Pencirian dan
Kajian Antibakteria Kompleks Kuprum (II) Tiosemikarbazon)
Omima
Abdalla1, 2, Yang Farina1*, Nazlina Ibrahim3
1School of
Chemical Sciences and Food Technology, Faculty of Science and Technology
Universiti Kebangsaan Malaysia, 43600
UKM Bangi, Selangor, Malaysia
2Department
of Chemistry, Faculty of Education,
University of Khartoum, Sudan
3School of Bioscience
and Biotechnology, Faculty of Science and Technology
Universiti
Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
*Corresponding author: farina@ukm.edu.my
Received: 6
July 2015; Accepted: 20 October 2015
Abstract
Reaction
of CuCl2.2H2O with 6-(3-thienyl)
pyridine-2-carboxaldehyde-4N-ethyl thiosemicarbazone, (HL1)
and 6-(3-thienyl) pyridine-2-carboxaldehyde-4N-phenylthiosemicarbazone,
(HL2) in ethanol produced the compounds [Cu(L1)Cl]2.2H2O
(1) and [Cu(HL)Cl2] (2) respectively. The ligands and complexes were
characterized by elemental analysis (C, H, N, and S), FT-IR, UV-visible,
magnetic susceptibility and molar conductance. The thiosemicarbazone is a
tridentate ligand coordinated via the pyridine nitrogen atom, the azomethine
nitrogen atom and the sulfur atom. The thiosemicarbazones may coordinate as
neutral oranionic ligands. The physicochemical and spectral data indicate a
square pyramidal geometry for copper (II) atoms. The thiosemicarbazone ligands
show moderate activity against bacteria MRSA and B.subtilis,
while the copper(II) complexes were very active against MRSA, B.subtilis and
B.thuringiensis and show moderate activity against S.aureus and
E.coli.
Keywords: thiosemicarbazone, Cu (II) complexes, antibacterial
study
Abstrak
Tindak balas garam CuCl2.2H2O
dengan 6- (3-thienyl)
piridina-2-karboksilaldehid-4N-etil tiosemikarbazon,
(HL1) dan 6- (3-thienyl) piridina-2-
karboksilaldehid-4N-feniltiosemikarbazon,
(HL2) dalam etanol menghasilkan masing-masing [Cu (L1) Cl]2.2H2O (1)
dan [Cu (HL)Cl2] (2). Ligan dan
kompleks telah dicirikan dengan analisis unsur (C, H, N, dan
S), FT-IR, UV-nampak,
kerentanan magnet dan kekonduksian molar. Tiosemikarbazon
adalah ligan tridentat
berkoordinat melalui atom nitrogen piridina,
atom nitrogen azometina dan ligan atom sulfur. Tiosemikarbazon boleh berkoordinat sebagai
ligan neutral atau anionik. Data fizikokimia
dan spektrum menunjukkan
geometri piramid segiempat
sama untuk atom kuprum(II). Ligan
tiosemikarbazon menunjukkan aktiviti sederhana terhadap bakteria MRSA dan B.subtilis,
manakala kompleks kuprum(II) sangat aktif terhadap MRSA,
B.subtilis dan B.thuringiensis dan menunjukkan aktiviti sederhana terhadap S.aureus dan E.coli.
Kata kunci: tiosemikarbazon, Cu (II) kompleks, kajian anti-bakteria
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