Malaysian Journal of Analytical Sciences Vol 19 No 6 (2015): 1171 - 1178

 

 

 

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL STUDY OF COPPER (II) COMPLEXES OF THIOSEMICARBAZONES

 

(Sintesis, Pencirian dan Kajian Antibakteria Kompleks Kuprum (II) Tiosemikarbazon)

 

Omima Abdalla1, 2, Yang Farina1*, Nazlina Ibrahim3

 

1School of Chemical Sciences and Food Technology, Faculty of Science and Technology

Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia

2Department of Chemistry, Faculty of Education,

University of Khartoum, Sudan

3School of Bioscience and Biotechnology, Faculty of Science and Technology

Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia

 

*Corresponding author: farina@ukm.edu.my

 

 

Received: 6 July 2015; Accepted: 20 October 2015

 

 

Abstract

Reaction of CuCl2.2H2O with 6-(3-thienyl) pyridine-2-carboxaldehyde-4N-ethyl thiosemicarbazone, (HL1) and 6-(3-thienyl) pyridine-2-carboxaldehyde-4N-phenylthiosemicarbazone, (HL2) in ethanol produced the compounds [Cu(L1)Cl]2.2H2O (1) and [Cu(HL)Cl2] (2) respectively. The ligands and complexes were characterized by elemental analysis (C, H, N, and S), FT-IR, UV-visible, magnetic susceptibility and molar conductance. The thiosemicarbazone is a tridentate ligand coordinated via the pyridine nitrogen atom, the azomethine nitrogen atom and the sulfur atom. The thiosemicarbazones may coordinate as neutral oranionic ligands. The physicochemical and spectral data indicate a square pyramidal geometry for copper (II) atoms. The thiosemicarbazone ligands show moderate activity against bacteria MRSA and B.subtilis, while the copper(II) complexes were very active against MRSA, B.subtilis and B.thuringiensis and show moderate activity against S.aureus and E.coli.

 

Keywords:  thiosemicarbazone, Cu (II) complexes, antibacterial study

 

Abstrak

Tindak balas garam CuCl2.2H2O dengan 6- (3-thienyl) piridina-2-karboksilaldehid-4N-etil tiosemikarbazon, (HL1) dan 6- (3-thienyl) piridina-2- karboksilaldehid-4N-feniltiosemikarbazon, (HL2) dalam etanol menghasilkan masing-masing [Cu (L1) Cl]2.2H2O (1) dan [Cu (HL)Cl2] (2). Ligan dan kompleks telah dicirikan dengan analisis unsur (C, H, N, dan S), FT-IR, UV-nampak, kerentanan magnet dan kekonduksian molar. Tiosemikarbazon adalah ligan tridentat berkoordinat melalui atom nitrogen piridina, atom nitrogen azometina dan ligan atom sulfur. Tiosemikarbazon boleh berkoordinat sebagai ligan neutral atau anionik. Data fizikokimia dan spektrum menunjukkan geometri piramid segiempat sama untuk atom kuprum(II). Ligan tiosemikarbazon menunjukkan aktiviti sederhana terhadap bakteria MRSA dan B.subtilis, manakala kompleks kuprum(II) sangat aktif terhadap MRSA, B.subtilis dan B.thuringiensis dan menunjukkan aktiviti sederhana terhadap S.aureus dan E.coli.

 

Kata kunci: tiosemikarbazon, Cu (II) kompleks, kajian anti-bakteria

 

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