Malaysian Journal of Analytical Sciences Vol 20 No 5 (2016): 971 - 977

DOI: http://dx.doi.org/10.17576/mjas-2016-2005-01

 

 

 

NEW INDOLIZIDINE ALKALOIDS FROM PSYCHROPHILIC YEAST Glyciozyma antarctica PI12

 

(Alkaloid Indolizidin Baharu daripada Yis Psikrofilik Glyciozyma antarctica PI12)

 

Andi Rifki Rosandy¹, Wickneswary Nadarajah², Muntaz Abu Bakar², Cheah Yoke Kqueen²,

Mohd. Ikram Mohd. Said², Laode Muhammad Ramadhan Al Muqarrabun³, Rozida Khalid¹*

 

¹School of Chemical Science and Food Technology, Faculty of Science and Technology,

Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia

²Department of Biomedical Sciences, Faculty of Medicine and Health Sciences,

 Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

³Atta-ur-Rahman Institute for Natural Product Discovery,

Universiti Teknologi MARA, Puncak Alam Campus, 43200 UiTM Puncak Alam, Selangor, Malaysia

 

*Corresponding author: rozidakhalid@ukm.edu.my

 

 

Received: 2 March 2016; Accepted: 10 May 2016

 

 

Abstract

Two alkaloid compounds: namely 3-(1-aminoethyl)tetrahydro-1H-pyrrolo[1,2-d][1,2,4]oxadiazine-1,4(3H)-dione (1) and tetrahydro-1H-pyrrolo[2,1-c][1,4]oxazine-1,3(4H)-dione (2) was isolated from Glyciozyma antarctica (PI12), a psychrophilic yeast. The isolated compounds were isolated by Radial Chromatography and Thin Layer Chromatography techniques. The chemical structures were elucidated by Ultraviolet-visible, Infrared, Nuclear Magnetic Resonance and Mass Spectroscopy.

 

Keywords:  Glyciozyma antarctica  PI12, alkaloids, yeast, psychrophiles

 

Abstrak

Dua sebatian alkaloid: 3-(1-aminoetil)tetrahidro-1H-pirrolo[1,2-d][1,2,4]oksadiazin-1,4(3H)-dion (1) and tetrahidro-1H-pirrolo[2,1-c][1,4]oksazin-1,3(4H)-dion (2) telah diasingkan daripada Glyciozyma antarctica PI12, sejenis yis psikrofilik. Sebatian-sebatian telah diasingkan menggunakan teknik Kromatografi Pepejal dan teknik Kromatografi Lapisan Nipis. Struktur-struktur kimia telah dicirikan dengan menggunakan Ultra-Lembayung, Infra-Merah, Resonans Magnet Nukleus dan Spektroskopi Jisim.    

 

Kata kunci: Glyciozyma antarctica PI12, alkaloid, yis, psikrofil

 

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