Sains Malaysiana 44(12)(2015): 1671–1676
Performance Comparison of Serum and Urine Biomarkers from Independent
Samples for Ovarian Cancer Screening
(Perbandingan Prestasi Serum dan Penanda Biologi
Urin daripada Sampel Bebas untuk Saringan Kanser Ovari)
HYE-JEONG SONG1,3, KI-SEOK JEONG2,3, JONG-DAE KIM1,3, CHAN-YOUNG PARK1,3 & YU-SEOP KIM*1,3
1Department
of Ubiquitous Computing, Hallym University, 1 Hallymdaehak-gil, Chuncheon,
Gangwon-do 200-702, Korea
2Department
of Computer Engineering, Hallym University, 1 Hallymdaehak-gil, Chuncheon,
Gangwon-do 200-702, Korea
3Bio
IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon,
Gangwon-do 200-702, Korea
Diserahkan: 2 September 2014/Diterima:
23 Jun 2015
ABSTRACT
This study compares the diagnostic performance of urine and serum
multiple biomarkers for early diagnosis of ovarian cancer. The sample
population includes 119 benign and 101 ovarian cancer patients.
The marker combinations used to compare performance include 16 markers
whose concentration values were obtained using the Luminex assay.
In order to identify an optimal marker combination that could classify
ovarian cancer and benign patients, the area under the curve (AUC) is used to evaluate 2-, 3-, and
4-marker combinations and the classification is performed by using
logistic regression. In the case of urine samples, the best AUC values
are 87.89% for the 2 protein markers combination, 90.22% for the
3 markers combination and 92.43% for the 4 marker combination. In
contrast, the best AUC
values for serum sample are 92.4% for the 2 marker
combination, 93.63% for the 3 marker combination and 94.63% for
the 4 marker combination. This study confirmed that combining multiple
biomarkers could improve diagnostic accuracy. Even though urine
sample shows relatively lower performance than serum, the urine
could be utilized more widely for its simple usability.
Keywords: Biomarker; ovarian cancer; serum; urine
ABSTRAK
Kajian ini membandingkan prestasi diagnostik air kencing dan
beberapa penanda biologi serum untuk diagnosis awal kanser ovari. Gabungan
penanda digunakan untuk membandingkan prestasi 16 penanda dan nilai kepekatan
diperoleh dengan menggunakan logam penguji Luminex. Untuk menentukan gabungan
penanda optimum yang boleh mengenal pasti kanser ovari dan pesakit biasa, luas
di bawah lengkungan (AUC) digunakan untuk menilai kombinasi
penanda 2-, 3- dan 4-. Pengelasan dijalankan dengan menggunakan regresi
logistik. Dalam kes sampel air kencing, nilai AUC yang
terbaik adalah 87.89% untuk 2 kombinasi penanda protein, 90.22% untuk 3
kombinasi penanda dan 92.43% untuk 4 kombinasi penanda. Sebaliknya, nilai AUC yang
terbaik untuk sampel serum adalah 92.4% untuk 2 kombinasi penanda, 93.63% untuk
3 kombinasi penanda dan 94.63% untuk 4 kombinasi penanda. Kajian ini
mengesahkan bahawa gabungan beberapa penanda biologi boleh meningkatkan
ketepatan diagnostik. Walaupun sampel air kencing menunjukkan prestasi yang
agak rendah daripada serum, air kencing boleh digunakan dengan lebih meluas
untuk kebolehgunaan yang mudah.
Kata kunci: Air kencing; kanser ovari; penanda biologi; serum
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*Pengarang untuk surat-menyurat; email: yskim01@hallym.ac.kr
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