 |
 |
 |
 |
 |
 |
Sains Malaysiana 47(11)(2018): 27052711 http://dx.doi.org/10.17576/jsm-2018-4711-14
Malaysian Tualang Honey and Its Potential Anti-Cancer Properties: A Review (Madu Tualang Malaysia dan Potensi Sifat Anti-Kansernya: Suatu Kajian) AHMAD FIRDAUS
BIN KHALID1, JUN
JIE
TAN2
& YOKE KEONG YONG1*
1Department of Human
Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra
Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia 2Advanced Medical and
Dental Institute, Universiti Sains Malaysia, Bertam, 13200 Kepala
Batas, Pulau Pinang, Malaysia Diserahkan: 8 Mac 2018/Diterima:
30 Julai 2018 ABSTRACT The use of honey as a therapeutic
agent dates back at 8000 years and has markedly increased interest
into its potential health benefits. The by-products of the flower
nectar have a complex chemical composition which promotes benefits
in underlying mechanism of human diseases. Malaysian Tualang Honey
(MTH) is a multifloral jungle honey produced by the rock
bee (Apis dorsata). This review consolidates the results
of carious studies involving biochemical assays of tissue culture
and animal trials of anti-cancer properties of MTH. Often studied in the context of
breast cancer cell lines, MTH has promising data for possible
mechanisms in anti-cancer activity. These include apoptosis via
depolarization of the mitochondrial membrane, caspase-dependent
apoptosis, reduction of angiogenesis and the promotion of cell
cycle arrest without posing cytotoxic effect on normal cell lines.
Despite positive outcomes in tissue cultures, the oral administration
of MTH in breast cancer animal models showed
slower tumour progression, reduction in tumour size and better
grading of histological features. The alleviation of breast carcinogenesis
via modulation of hematologic, estrogenic and apoptotic activities
promotes MTH
as a promising anticancer agent. With confidence
in a conclusion that MTH
is a useful treatment for cancer, further experimental
and clinical studies should be conducted. Keywords: Anti-cancer; anti-proliferative;
breast cancer; Malaysian Tualang Honey ABSTRAK Penggunaan madu sejak 8000
tahun yang lalu sebagai agen terapeutik telah meningkat dengan
ketara kerana potensi manfaatnya kepada kesihatan. Produk sampingan
daripada nektar bunga ini mempunyai komposisi kimia yang kompleks
dan menpromosikan manfaat untuk mengubati penyakit manusia pada
peringkat asas mekanisme penyakit tersebut. Madu Tualang Malaysia
(MTH) adalah madu hutan pelbagai jenis
flora yang dihasilkan oleh lebah Tualang, lebah madu gergasi atau
dikenali sebagai naning (Apis dorsata). Kertas ini melaporkan keputusan pelbagai kajian
yang melibatkan ujian biokimia untuk menguji sifat anti-kanser
MTH yang
dijalankan terhadap kultur tisu dan model haiwan. Kajian yang
dijalankan ke atas sel selanjar kanser payudara menunjukkan bahawa
MTF mempunyai
aktiviti anti-kanser. Perkara ini termasuklah apoptosis melalui
depolarisasi membran mitokondria, apoptosis bersandarkan-caspase,
pengurangan angiogenesis dan pemberhentian kitaran sel tanpa mempunyai
kesan sitotoksik terhadap sel selanjar normal. Walaupun kesan
positif MTF terhadap kultur sel, pemberian
MTH secara oral kepada model kanser payudara haiwan menunjukkan
bahawa MTH memperlahankan perkembangan tumor,
mengurangkan saiz tumor dan membaiki gred histologi sel tumor.
Kesan MTH
terhadap pengurangan karsinogenesis payudara melalui
modulasi aktiviti hematologi, estrogen dan apoptosis memungkinkan
MTH menjadi agen anti-kanser yang berpotensi.
Untuk memperoleh keputusan yang lebih meyakinkan bahawa MTH
boleh menjadi rawatan yang berguna untuk kanser,
uji kaji lanjutan dan kajian klinikal perlu dilakukan. Kata kunci: Anti-kanser;
anti-proliferasi; kanser payudara; Madu Tualang Malaysia RUJUKAN Abdulrasheed,
I., Zira, D.I. & Eneye, A.M. 2011. Modification of the surgical
morbidity and mortality meetings as a tool to improve patient
safety. Oman Medical Journal 26: 290-292. Ahmed,
S. & Othman, N.H. 2017. The anti-cancer effects of Tualang
honey in modulating breast carcinogenesis: An experimental animal
study. BMC Complementary and Alternative Medicine 17: 208.
Ahmed, S. & Othman,
N.H. 2013. Review of the medicinal effects of Tualang honey and
a comparison with Manuka Honey. The Malaysian Journal of Medical
Sciences: MJMS 20: 6-13. Ahmed, S., Sulaiman, S.A. & Othman,
N.H. 2017. Oral administration of Tualang and Manuka honeys modulates
breast cancer progression in Sprague-Dawley rats model. Evidence-Based
Complementary and Alternative Medicine 2017: 5904361. Attia, W.Y., Gabry,
M.S., EL-Shaikh, K.A. & Othman, G.A. 2008. The anti-tumor
effect of bee honey in Ehrlich ascite tumor model of mice is coincided
with stimulation of the immune cells. The Egyptian Journal
of Immunology 15: 169-183. Azizah, Ab.M.,
Nor Saleha, I.Y., Noor Hashimah, A., Asmah, Z. & Mastulu,
W. 2016. National Cancer Registry Report 2007-2011: Malaysia
Cancer Statistic, Data and Figure. Putrajaya: National Cancer
Registry. Ball, D. 2007.
The Chemical Composition of Honey. Journal of Chemical Education
84: 1643. Bentzen, S.M. 2006.
Preventing or reducing late side effects of radiation therapy:
Radiobiology meets molecular pathology. Nature Reviews Cancer
6: 702-713. Cancer Research
UK. http://www.cancerresearchuk.org/health-professional/cancer-statistics/worldwide-cancer.
Accessed on 2 January 2018. Deckbar, D., Jeggo,
P.A. & Löbrich, M. 2011. Understanding the limitations of
radiation-induced cell cycle checkpoints. Critical Reviews
in Biochemistry and Molecular Biology 46: 271-283. Dustmann, J.H.
1979. Antibacterial effect of honey. Apiacta 14: 7-11.
Dy, G.K. &
Adjei, A.A. 2008. Systemic cancer therapy: Evolution over the
last 60 years. Cancer 113: 1857-1887. El-Arab, A.M.E.,
Girgis, S.M., Hegazy, E.M. & El-Khalek, A.B.A. 2006. Effect
of dietary honey on intestinal microflora and toxicity of mycotoxins
in mice. BMC Complementary and Alternative Medicine 6:
6. https://doi.org/10.1186/1472- 6882-6-6. Estevinho, L.,
Pereira, A., Moreira, L., Dias, L. & Pereira, E. 2008. Antioxidant
and antimicrobial effects of phenolic compounds extracts of Northeast
Portugal honey. Food and Chemical Toxicology 46: 3774-3779.
Eteraf-Oskouei,
T. & Najafi, M. 2013. Traditional and modern uses of natural
honey in human diseases: A review. Iranian Journal of Basic
Medical Sciences 16: 731-742. Fauzi, A.N. &
Yaacob, N.S. 2016. Cell cycle and apoptosis pathway modulation
by Tualang honey in ER-dependent and-independent breast cancer
cell lines. Journal of Apicultural Research 55: 366-374.
Fauzi, A., Norazmi,
M. & Yaacob, N. 2011. Tualang honey induces apoptosis and
disrupts the mitochondrial membrane potential of human breast
and cervical cancer cell lines. Food and Chemical Toxicology
49: 871-878. Fisher, B., Costantino,
J.P., Redmond, C.K., Fisher, E.R., Wickerham, D.L. Cronin, W.M.
& NSABP Contributors. 1994. Endometrial cancer in tamoxifen-treated
breast cancer patients: Findings from the National Surgical Adjuvant
Breast and Bowel Project (NSABP) B -14. JNCI: Journal of the
National Cancer Institute 86: 527-537. Ghashm, A., Othman,
N., Khattak, M., Ismail, N. & Saini, R. 2010. Antiproliferative
effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma
cell lines. BMC Complementary and Alternative Medicine 10:
49. Gheldof, N. &
Engeseth, N. 2002. Antioxidant capacity of honeys from various
floral sources based on the determination of oxygen radical absorbance
capacity and inhibition of in vitro lipoprotein oxidation
in human serum samples. Journal of Agricultural and Food Chemistry
50: 3050-3055. Glaser, S.L., Hsu,
J.L. & Gulley, M.L. 2004. Epstein-Barr virus and breast cancer:
State of the evidence for viral carcinogenesis. Cancer Epidemiology
and Prevention Biomarkers 13: 688-697. Gómez-Caravaca,
A., Gómez-Romero, M., Arráez-Román, D., Segura-Carretero, A. &
Fernández-Gutiérrez, A. 2006. Advances in the analysis of phenolic
compounds in products derived from bees. Journal of Pharmaceutical
and Biomedical Analysis 41: 1220-1234. Halima, A.S., Kirnpal-Kaur,
B.S., Doraia, A.A., Amana, W.S. & Khooa, Y.T. 2010. Wound
contraction and anti-microbial properties of Tualang honey on
full thickness burn wound in rats. Journal of ApiProduct and
ApiMedical Science 2: 31-60. Hernandez, R.K.,
Sřrensen, H.T., Pedersen, L., Jacobsen, J. & Lash, T.L. 2009.
Tamoxifen treatment and risk of deep venous thrombosis and pulmonary
embolism. Cancer 115: 4442-4449. Hsieh, C.C., Trichopoulos,
D., Katsouyanni, K. & Yuasa, S. 1990. Age at menarche, age
at menopause, height and obesity as risk factors for breast cancer:
Associations and interactions in an international case-control
study. International Journal of Cancer 46: 796-800. Hsu, C.C., Tseng,
L.M. & Lee, H.C. 2016. Role of mitochondrial dysfunction in
cancer progression. Experimental Biology and Medicine 241:
1281-1295. Hu, R., Hilakivi-Clarke,
L. & Clarke, R. 2015. Molecular mechanisms of tamoxifen-associated
endometrial cancer. Oncology Letters 9: 1495-1501. Hudson, M.M., Ness,
K.K., Gurney, J.G., Mulrooney, D.A., Chemaitilly, W., Krull, K.R.,
Green, D.M., Armstrong, G.T., Nottage, K.A., Jones, K.E. &
Sklar, C.A. 2013. Clinical ascertainment of health outcomes among
adults treated for childhood cancer. JAMA 309: 1371-2381.
Iurlina, M.O.,
Saiz, A.I., Fritz, R. & Manrique, G.D. 2009. Major flavonoids
of Argentinean honeys. Optimisation of the extraction method and
analysis of their content in relationship to the geographical
source of honeys. Food Chemistry 115: 1141-1149. Kadir, E.A., Sulaiman,
S.A., Yahya, N.K. & Othman, N.H. 2013. Inhibitory effects
of Tualang honey on experimental breast cancer in rats: A preliminary
study. Asian Pacific Journal of Cancer Prevention 14: 2249-2254.
Kakonienė,
V. & Venskutonis, P. 2010. Floral markers in honey of various
botanical and geographic origins: A review. Comprehensive Reviews
in Food Science and Food Safety 9: 620-634. Kakonienė,
V., Venskutonis, P.R. & Čeksterytė, V. 2010. Carbohydrate
composition and electrical conductivity of different origin honeys
from Lithuania. LWT-Food Science and Technology 43: 801-807.
Khalil, M.I., Alam,
N., Moniruzzaman, M., Sulaiman, S.A. & Gan, S.H. 2011. Phenolic
acid composition and antioxidant properties of Malaysian honeys.
Journal of Food Science 76: C921-C928. King, M.C., Marks,
J.H. & Mandell, J.B. 2003. Breast and ovarian cancer risks
due to inherited mutations in BRCA1 and BRCA2. Science 302:
643-646. Kishore, R., Halim,
A., Syazana, M. & Sirajudeen, K. 2011. Tualang honey has higher
phenolic content and greater radical scavenging activity compared
with other honey sources. Nutrition Research 31: 322-325.
Man, N., Khuzaimi, N.M., Hassan,
R., Ang, C.Y., Abdullah, A.D., Radzi, M., Rasheeq, M.A. &
Sulaiman, S.A. 2015. Antileukemic effect
of tualang honey on acute and chronic leukemia cell lines. BioMed
Research International 2015: 307094. Mann, J. 2002. Natural
products in cancer chemotherapy: Past, present and future. Nature
Reviews Cancer 2: 143-148. Michot, J.M., Bigenwald,
C., Champiat, S., Collins, M., Carbonnel, F., Postel-Vinay, S.,
Berdelou, A., Varga, A., Bahleda, R., Hollebecque, A. & Massard,
C. 2016. Immune-related adverse events with immune checkpoint
blockade: A comprehensive review. European Journal of Cancer
54: 139-148. Million Women Study
Collaborators. 2003. Breast cancer and hormone-replacement therapy
in the Million Women Study. Lancet 362: 419-427. Mohamed, M., Sirajudeen,
K., Swamy, M., Yaacob, N. & Sulaiman, S. 2010. Studies on
the antioxidant properties of Tualang honey of Malaysia. African
Journal of Traditional, Complementary and Alternative Medicines
7: 59-63. Moniruzzaman, M., Khalil,
M.I., Sulaiman, S.A. & Gan, S.H. 2013. Physicochemical and
antioxidant properties of Malaysian honeys produced by Apis
cerana, Apis dorsata and Apis mellifera. BMC Complementary
and Alternative Medicine 13:
43. Nasir, N., Halim, A.,
Singh, K., Dorai, A. & Haneef, M. 2010. Antibacterial properties
of Tualang honey and its effect in burn wound management: A comparative
study. BMC Complementary and Alternative Medicine 10: 31.
Nosrati, N., Bakovic,
M. & Paliyath, G. 2017. Molecular mechanisms and pathways
as targets for cancer prevention and progression with dietary
compounds. International Journal of Molecular Sciences 18:
2050. Nussbaumer, S., Bonnabry,
P., Veuthey, J.L. & Fleury-Souverain, S. 2011. Analysis of
anticancer drugs: A review. Talanta 85: 2265-2289. Ohno, T., Yanai, M.,
Ando, H., Toyomasu, Y., Ogawa, A., Morita, H., Ogata, K., Mochiki,
E., Asao, T. & Kuwano, H. 2011. Rikkunshito, a traditional
Japanese medicine, suppresses cisplatin-induced anorexia in humans.
Clinical and Experimental Gastroenterology 4: 291-196.
Olaitan, P.B., Adeleke,
O.E. & Lyabo, O. 2007. Honey: A reservoir for microorganisms
and an inhibitory agent for microbes. African Health Sciences
7: 159-165. Pardoll, D.M. 2012.
The blockade of immune checkpoints in cancer immunotherapy. Nature
Reviews Cancer 12: 252-264. Pichichero, E., Cicconi,
R., Mattei, M., Muzi, M. & Canini, A. 2010. Acacia honey and
chrysin reduce proliferation of melanoma cells through alterations
in cell cycle progression. International Journal of Oncology
37: 973-981. Raji, M.A. 2005. Management
of chemotherapy-induced side-effects. The Lancet Oncology 6:
357. Rao, P.V., Krishnan,
K.T., Salleh, N. & Gan, S.H. 2016. Biological and therapeutic
effects of honey produced by honey bees and stingless bees: A
comparative review. Revista Brasileira de Farmacognosia 26:
657-664. Riddle, J. 2014. Dioscorides
on Pharmacy and Medicine. 1st ed. Austin: University of Texas
Press. Sakarkar, D.M. &
Deshmukh, V.N. 2011. Ethnopharmacological review of traditional
medicinal plants for anticancer activity. International Journal
of Pharmtech Research 3: 298-308. Schünemann, M., Anker,
S.D. & Rauchhaus, M. 2008. Cancer fatigue syndrome reflects
clinically non-overt heart failure: An approach towards oncocardiology.
Nature Reviews Clinical Oncology 5: 632-633. Stephens, J.M., Greenwood,
D.R., Feamley, L., Bong, J., Schlothauer, R.C. & Loomes, K.M.
2015. Honey production and compositional parameters. In Processing
and Impact on Active Components in Food, edited by Preedy,
V. London: Academic Press. pp. 675-680. Sudhakar, A. 2009. History
of cancer, ancient and modern treatment methods. Journal of
Cancer Science and Therapy 1: 1-4. Tan, J.J., Azmi, S.M.,
Yong, Y.K., Cheah, H.L., Lim, V., Sandai, D. & Shaharuddin,
B. 2014. Tualang honey improves human corneal epithelial progenitor
cell migration and cellular resistance to oxidative stress in
vitro. PloS One 9: e96800. Valko, M., Leibfritz,
D., Moncol, J., Cronin, M.T.D., Mazur, M. & Telser, J. 2007.
Free radicals and antioxidants in normal physiological functions
and human disease. The International Journal of Biochemistry
and Cell Biology 39: 44-84. Wen, S., Zhu, D. &
Huang, P. 2013. Targeting cancer cell mitochondria as a therapeutic
approach. Future Medicinal Chemistry 5: 53-67. World Health Organization.
http://www.who.int/mediacentre/ factsheets/fs297/en/. Accessed
on 2 January 2018. Yaacob, N.S. & Ismail,
N.F. 2014. Comparison of cytotoxicity and genotoxicity of 4-hydroxytamoxifen
in combination with Tualang honey in MCF-7 and MCF-10A cells.
BMC Complementary and Alternative Medicine 14: 106. Yaacob, N.S., Nengsih,
A. & Norazmi, M. 2013. Tualang honey promotes apoptotic cell
death induced by tamoxifen in breast cancer cell lines. Evidence-Based
Complementary and Alternative Medicine 2013: 989841. Yoshida, N., Hosokawa,
T., Ishikawa, T., Yagi, N., Kokura, S., Naito, Y., Nakanishi,
M., Kokuba, Y., Otsuji, E., Kuroboshi, H. & Taniwaki, M. 2013.
Efficacy of goshajinkigan for oxaliplatin-induced peripheral neuropathy
in colorectal cancer patients. Journal of Oncology 2013:
139740. Zainol, M.I., Yusoff,
K.M. & Yusof, M.Y.M. 2013. Antibacterial activity of selected
Malaysian honey. BMC Complementary and Alternative Medicine
13: 129. *Pengarang
untuk surat-menyurat; email: yoke_keong@upm.edu.my
|
|||
|
