Sains Malaysiana 49(4)(2020): 825-838

http://dx.doi.org/10.17576/jsm-2020-4904-12

 

Mesenchymal Stem Cell Therapy for Sports Injuries - From Research to Clinical Practice

(Terapi Sel Stem Mesenkima untuk Kecederaan Sukan - Daripada Kajian kepada Amalan Klinikal)

 

QI HAO LOOI1, SUE PING ENG1, LING LING LIAU2, YIN SIM TOR3, MOHD YAZID BAJURI4, MIN HWEI NG5 & JIA XIAN LAW5*

 

1Ming Medical Services Sdn. Bhd., Pusat Perdagangan Dana 1, 47301 Petaling Jaya Selangor Darul Ehsan, Malaysia

 

2Physiology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000, Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

3School of Biosciences, Faculty of Health & Medical Sciences, Taylor’s University, 47500 Subang Jaya, Selangor Darul Ehsan, Malaysia

 

4Orthopaedic Department, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000, Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

5Tissue Engineering Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000, Cheras, Kuala Lumpur Federal Territory, Malaysia

 

Diserahkan: 15 Mei 2019/Diterima: 19 Disember 2019

 

Abstract

The number of sports-related injuries is on the rise as more people are involved in sports, especially the extreme sports that are prone to injury. A serious sports injury might end the career of an athlete. Thus, prompt and effective treatment is very important for these injuries. Cell-based therapy is becoming more popular as a potential new treatment for sports injuries that are refractory to conventional therapy. Mesenchymal stem cells (MSCs) are commonly used in the treatment of sports injuries as they are safe and will not be rejected by the recipient. MSCs secrete paracrine factors that modulate the host immune response, promote angiogenesis, enhance cell migration and survival as well as prevent fibrosis. The safety and efficacy of MSC therapy in treating sports injuries involving the muscle, ligament, tendon, bone, cartilage, and nervous tissues have been demonstrated in many preclinical and clinical studies. However, more studies especially the large-scale randomized clinical trial need to be done in order to determine the adequacy of MSC therapy in treating different sports injuries. In this review, we discussed the treatment for sports injuries, focusing on MSC therapy, using data from preclinical and clinical studies.

 

Keywords: Mesenchymal stem cell; orthopedics; regenerative medicine; sports injury; stem cell therapy

 

Abstrak

Bilangan kes kecederaan berkaitan dengan sukan semakin meningkat sejajar dengan peningkatan bilangan orang yang aktif dalam sukan, terutamanya sukan lasak yang senang tercedera. Kerjaya seorang atlet mungkin ditamatkan oleh kecederaan berkaitan dengan sukan yang serius. Oleh yang demikian, rawatan segera dan berkesan amat penting untuk kecederaan ini. Terapi sel menjadi semakin popular sebagai rawatan baharu untuk kecederaan berkaitan dengan sukan yang refraktori kepada terapi konvensional. Sel induk mesenkima (MSC) kerap digunakan untuk rawatan kecederaan berkaitan dengan sukan kerana ia adalah lebih selamat dan tidak akan ditolak oleh sistem imun penerima. MSC merembeskan faktor parakrin yang memodulasi tindak balas imuniti, merangsang angiogenesis, migrasi sel dan kemandirian sel serta mencegah fibrosis. Keselamatan dan efikasi terapi MSC dalam merawat kecederaan berkaitan dengan sukan yang melibatkan tisu otot, ligamen, tendon, tulang, rawan dan saraf telah ditunjukkan dalam banyak kajian praklinikal dan klinikal. Namun demikian, lebih banyak kajian terutamanya percubaan klinikal terawak berskala besar perlu dijalankan untuk mengenal pasti kepadanan terapi MSC dalam menangani kecederaan berkaitan dengan sukan yang berbeza. Di sini kami membincangkan rawatan untuk kecederaan berkaitan dengan sukan menggunakan data daripada kajian preklinikal dan klinikal dengan fokus diberikan kepada terapi MSC.

 

Kata kunci: Kecederaan berkaitan dengan sukan; sel induk mesenkima; ortopedik; perubatan regeneratif; terapi sel

 

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