Malaysian Journal of Analytical Sciences Vol 19 No 3 (2015): 503 – 512

 

 

 

SAGO STARCH BASED HYDROGEL PREPARED USING ELECTRON BEAM IRRADIATION TECHNIQUE FOR CONTROLLED RELEASE APPLICATION

 

  (Hidrogel berasaskan kanji sagu disedia menggunakan teknik radiasi alur elektron untuk aplikasi pelepasan terkawal)

 

Zakiah Jamingan¹, Mansor B. Ahmad¹*, Kamaruddin Hashim², Norhazlin Zainuddin¹

 

¹Department of Chemistry,

Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

²Malaysian Nuclear Agency (Nuclear Malaysia),

43000 Kajang, Selangor, Malaysia

 

*Corresponding author: mansorahmad@upm.edu.my

 

 

Received: 1 April 2015; Accepted: 23 April 2015

 

 

Abstract

Carboxymethyl Sago starch (CMSS) is one of the natural polymers with high value as a polymeric device for medical application due to its potential as biocompatible materials. The monomer blending with modified natural polymers by irradiation technique has received wide attention due to the simple method of preparation, more promising material and free chemical residue in the product. CMSS/methacrylic acid (MAA) hydrogels were synthesized by Electron Beam irradiation at 2meV, 10mA. The objective of this study was to evaluate the ability of hydrogels from modified carboxymethyl sago starch CMSS for oral drug delivery. The hydrogels were characterized by FT-IR, TGA and DTG. The effects of the preparation conditions such as the, monomer composition and irradiation dose on the gel fraction of the synthesized hydrogel were investigated. The swelling properties of the hydrogel were carried out in acidic media, neutral and alkaline media at different temperatures (27˚C – 60 ˚C). The pH sensitive properties of CMSS/MAA hydrogel showed that it can be used as drug delivery devices due to suitability of pH response to the environment in gastrointestine tract.

 

Keywords: carboxymethyl sago starch, hydrogels, controlled release

 

Abstrak

Karboksimetil kanji sagu (CMSS) adalah salah satu polimer semula jadi yang mempunyai nilai tinggi sebagai peranti polimer untuk aplikasi perubatan kerana berpotensi sebagai bahan bioserasi. Adunan monomer dengan polimer semulajadi yang dimodifikasi dengan teknik penyinaran telah menerima perhatian yang meluas kerana kaedah penyediaan yang mudah, bahan yang lebih berkualiti terhasil dan tiada sisa kimia dalam produk tersebut. Hidrogel CMSS/asid metakrilik (MAA) disintesis menggunakan penyinaran alur elektron pada kondisi 2meV, 10mA. Objektif kajian ini adalah untuk menilai kemampuan hidrogel daripada karboksimetil yang telah diubahsuai daripada kanji sagu, untuk penghantaran ubat secara oral. Hidrogel telah dicirikan menggunakan FT-IR, TGA dan DTG. Kesan daripada keadaan persediaan seperti komposisi monomer dan dos sinaran ke atas hidrogel yang disintesis telah diselidik. Sifat pembengkakan hidrogel dalam media berasid, neutral dan alkali pada suhu yang berbeza (27 ºC - 60 ºC) juga diuji. Sifat sensitif yang ditunjukkan oleh hidrogel terhadap pH telah menjadikannya sesuai untuk digunakan sebagai alat pembawa ubat kerana kesesuaian respon pH kepada persekitaran dalam saluran gastrousus.

 

Kata kunci: karboksimetil-kanji sagu, hidrogel, pelepasan terkawal

 

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