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Sains Malaysiana 52(4)(2023):
http://doi.org/10.17576/jsm-2023-5204-12
Fe/ZSM-5-Catalyzed-Synthesis
of 1,4-Dihydropyridines under Ultrasound Irradiation and Their Antioxidant
Activities
(Fe/ZSM-5-Pemangkin-Sintesis 1,4-Dihidropiridin di
Bawah Sinaran Ultrabunyi dan Aktiviti Antioksidannya)
YAYAN
DWI SUTARNI, BAMBANG PURWONO, EKO SRI KUNARTI & MUHAMMAD IDHAM DARUSSALAM
MARDJAN*
Department of Chemistry, Faculty of Mathematics and
Natural Sciences, Universitas Gadjah Mada, Yogyakarta
55281, Indonesia
Received: 24 July
2022/Accepted: 26 February 2023
Abstract
A
small library of 1,4-dihydropyridines have been synthesized from ethyl
acetoacetate, ammonium acetate and various aldehydes via Hantzsch multicomponent
reaction in the presence of Fe/ZSM-5 catalyst under ultrasound irradiation for
90 min. 1,4-Dihydropyridine derivatives were obtained in 64-86% yields and the
heterogeneous Fe/ZSM-5 catalyst can be employed for four reaction cycles
without losing the catalytic activity. All products were evaluated for their
antioxidant activities using the DPPH method and compound 4g was found
to be an effective antioxidant agent with DPPH activity of 83.5%.
Keywords: Antioxidant assay; Fe/ZSM-5 catalyst;
ultrasound-assisted-multicomponent reaction; 1,4-dihydropyridines
Abstrak
Terbitan 1,4-dihidropiridin telah disintesis daripada etil asetoasetat,
ammonium asetat, dan pelbagai aldehid melalui tindak balas pelbagai komponen Hantzsch yang dimangkinkan oleh Fe/ZSM-5 di bawah penyinaran ultrabunyi selama 90 minit. Terbitan 1,4-dihidropiridin diperoleh dengan hasil 64-86% dan mangkin heterogen Fe/ZSM-5 boleh digunakan untuk 4 kitaran tindak balas tanpa kehilangan aktiviti pemangkin. Semua produk telah dinilai untuk aktiviti antioksidannya menggunakan kaedah DPPH dan sebatian 4g didapati sebagai agen antioksidan yang berkesan dengan aktiviti DPPH sebesar 83.5%.
Kata kunci: Pemangkin Fe/ZSM-5; tindak balas pelbagai komponen dibantu ultrabunyi; ujian antioksidan; 1,4-dihidropiridin
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*Corresponding author; email: idham.darussalam@ugm.ac.id
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