Sains Malaysiana 40(5)(2011): 467–473
Association Between Dialysis Dose and
Biochemical Blood Parameters
(Hubungan antara Dos Dialisis dan Parameter Biokimia)
Nur Zakiah Mohd. Saat1, *, Sazlina Kamaralzaman2 Norshafarina Shaari1 & Farida Zuraina Mohd. Yusoff3
1Department of Biomedical Science, Faculty of Allied Health
Science
Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia
2Programme of Ocupational Theraphy, Faculty of Allied Health
Science
Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia
3Faculty of Applied Sciences, Universiti Teknologi MARA
40450 Shah Alam, Selangor, Malaysia
Diserahkan: 12 Mac 2010 / Diterima: 15 Julai 2010
ABTRACT
The end stage renal
disease (ESRD) patients requires hemodialysis to survive. Efficacy
of the treatment is determined by evaluation of minimal dialysis dose (Kt/V)
which is 1.2. A cross sectional study was conducted among patients that undergo
hemodialysis in a dialysis centre in Kuala Lumpur, Malaysia. The objectives of
the study were to determine the association between dialysis dose and
demographic factors and assessed the association between biochemical blood
parameter and the demographic factors. The biochemical blood parameters were
serum albumin, creatinine, cholesterol and hemoglobin. Result showed that all
Indians and 54% of Chinese patients achieved the required dialysis dose.
However only 29% of Malay patients attained the effective dialysis dose. More
women patients accomplished the dialysis dose of at least 1.2 compared to men
patients with odd ratio of 11.24. All the biochemical blood parameters were
independent of the demographic factors. However, the cholesterol level was
associated significantly with gender (p<0.05). In conclusion, the study
found the biochemical blood parameter and dialysis dose were not influenced by
the demographic factors.
Keywords: Biochemical
blood parameters; dialysis dose; end stage renal disease; hemodialysis
ABSTRAK
Pesakit yang mengalami
kegagalan renal peringkat lewat (ESRD) perlu menjalani rawatan
hemodialisis untuk meneruskan kehidupan. Kerbekesanan rawatan ditentukan
berdasarkan kepada dos dialisis (Kt/V) iaitu 1.2. Suatu kajian keratan rentas
telah dijalankan ke atas pesakit yang menerima rawatan hemodialisis di pusat dialisis
di Kuala Lumpur, Malaysia. Objektif kajian ini adalah untuk menentukan hubungan
antara dos dialisis dengan faktor demografi. Kedua, kajian ini juga ingin
menentukan hubungan antara parameter biokimia dan faktor demografi. Parameter
biokimia adalah serum albumin, kreatinin, kolesterol dan hemoglobin. Hasil
kajian menunjukkan bahawa kesemua pesakit berbangsa India dan 54% pesakit
berbangsa Cina mencapai dos dialisis yang diperlukan. Walau bagaimanapun, hanya
29% pesakit berbangsa Melayu mencapai dos yang efektif. Lebih ramai pesakit
wanita yang mencapai dos dialisis sekurang-kurangnya 1.2 berbanding dengan
pesakit lelaki dengan nisbah odds 11.24. Kesemua parameter biokimia adalah
tidak bersandar dengan faktor demografi. Walau bagaimanapun aras kolesterol
mempunyai hubungan yang signifikan dengan faktor jantina (p<0.05).
Kesimpulannya, kajian ini menunjukkan bahawa parameter biokimia dan dos
dialisis tidak mempunyai perkaitan dengan faktor demografi.
Kata kunci: Dos
dialisis; hemodialisis; kegagalan renal peringkat lewat; parameter biokimia
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*Pengarang untuk
surat-menyurat; email: nurza@medic.ukm.my
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