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Single Nucleotide Polymorphism for Certain Genes Involved in Gestational Diabetes with Risk Factors and Complications Positive (Polimorfisme Nukleotida Tunggal bagi Gen Tertentu yang Terlibat
dalam Faktor Risiko
dan Komplikasi Positif Diabetes Gestasi)
NOR AZLIN MOHAMED
ISMAIL1*, NORKHATIJAH
MOHD
ARIS1, ZALEHA
ABDULLAH
MAHDY1, SHUHAILA
AHMAD1, NORZILAWATI
MOHD
NAIM1, HARLINA
HARLIZAH
SIRAJ1, ROHANA
JAAFAR2, SHAREENA
ISHAK2, ROSLAN
HARUN3,
1Department of Obstetrics & Gynaecology, Faculty of Medicine,
Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff 56000 Cheras, Kuala Lumpur, Malaysia 2Department of Paediatrics, Faculty of Medicine Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000
Cheras, Kuala Lumpur, Malaysia Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia Diserahkan:
19 Julai 2012/Diterima: 9 April 2013
ABSTRACT
Gestational Diabetes Mellitus (GDM)
is associated with pregnancy complications, however its mechanism has not been
fully understood. The aim of this study was to investigate the single
nucleotide polymorphism (SNP) for identifying candidate genes
involve in risk factors and complications of GDM.
A total of 174 pregnant women with GDM and 114 healthy pregnant
women were genotyped with 384 SNPs from 236 genes. The SNPs
identified were rs10946398 (CDKAL1) in GDM risk
factors; rs328 (LPL) and
rs1042778 (OXTR) in
complications of caesarean section; rs5404 (SLC2A2),
rs5400 (SLC2A2) and rs13306465 (IRS1) for neonatal intensive care
admission. Whereby SNPs rs12255372, rs7901695 and
rs7903146 from TCF7L2 gene had six times higher risk
(OR, 6.40-6.53) for T2DM at
postpartum. In conclusion, although the above SNPs
were identified with GDM risk factors and complications
among pregnant Malaysian women with GDM, a larger study is needed
to ascertain this candidate genes actual association.
Keywords: Complications; gestational diabetes mellitus; single
nucleotide polymorphisms; risks; Malaysia
ABSTRAK
Diabetes Melitus Gestasi (GDM)
mempunyai perkaitan dengan komplikasi kehamilan, namun demikian
mekanismenya masih belum dikenal pasti sepenuhnya. Kajian ini adalah untuk mengkaji polimorfisme
nukleotida tunggal (SNP) bagi mengenal pasti gen yang terlibat
dalam faktor risiko GDM dan komplikasinya. Sejumlah
174 wanita hamil dengan GDM and 114 wanita hamil yang sihat telah
digenotip dengan 384 SNPs daripada 236 gen. SNPs
yang dikenal pasti adalah rs10946398 (CDKAL1) dalam faktor risiko GDM; rs328 (LPL)
dan rs1042778 (OXTR) dalam komplikasi
pembedahan caesarean; rs5404 (SLC2A2),
rs5400 (SLC2A2) dan rs13306465 (IRS1) untuk kemasukan wad rawatan rapi neonatal.
Sementara SNPs rs12255372, rs7901695 dan
rs7903146 daripada gen TCF7L2 mempunyai enam kali lebih tinggi
risiko (OR, 6.40-6.53) untuk
T2DM
semasa postpartum. Sebagai kesimpulan, walaupun
SNPs
di atas telah dikenal pasti dengan faktor risiko GDM dan
komplikasinya dalam kalangan wanita Malaysia yang hamil dengan Diabetes
Gestasi, satu kajian yang lebih besar adalah perlu bagi memastikan
penglibatan sebenar gen tersebut.
Kata kunci: Diabetes melitus gestasi; komplikasi; polimorfisme nukleotida tunggal; risiko; Malaysia
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