Sains Malaysiana 40(5)(2011): 467–473

Association Between Dialysis Dose and Biochemical Blood Parameters

(Hubungan antara Dos Dialisis dan Parameter Biokimia)

Nur Zakiah Mohd. Saat^1, *, Sazlina Kamaralzaman²  Norshafarina Shaari¹ & Farida Zuraina Mohd. Yusoff³

¹Department of Biomedical Science, Faculty of Allied Health Science

Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia

²Programme of Ocupational Theraphy, Faculty of Allied Health Science

Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia

³Faculty of Applied Sciences, Universiti Teknologi MARA

40450 Shah Alam, Selangor, Malaysia

Received: 12 March 2010 / Accepted: 15 July 2010

ABTRACT

The end stage renal disease (ESRD) patients requires hemodialysis to survive. Efficacy of the treatment is determined by evaluation of minimal dialysis dose (Kt/V) which is 1.2. A cross sectional study was conducted among patients that undergo hemodialysis in a dialysis centre in Kuala Lumpur, Malaysia. The objectives of the study were to determine the association between dialysis dose and demographic factors and assessed the association between biochemical blood parameter and the demographic factors. The biochemical blood parameters were serum albumin, creatinine, cholesterol and hemoglobin. Result showed that all Indians and 54% of Chinese patients achieved the required dialysis dose. However only 29% of Malay patients attained the effective dialysis dose. More women patients accomplished the dialysis dose of at least 1.2 compared to men patients with odd ratio of 11.24. All the biochemical blood parameters were independent of the demographic factors. However, the cholesterol level was associated significantly with gender (p<0.05). In conclusion, the study found the biochemical blood parameter and dialysis dose were not influenced by the demographic factors.

Keywords: Biochemical blood parameters; dialysis dose; end stage renal disease; hemodialysis

ABSTRAK

Pesakit yang mengalami kegagalan renal peringkat lewat (ESRD) perlu menjalani rawatan hemodialisis untuk meneruskan kehidupan. Kerbekesanan rawatan ditentukan berdasarkan kepada dos dialisis (Kt/V) iaitu 1.2. Suatu kajian keratan rentas telah dijalankan ke atas pesakit yang menerima rawatan hemodialisis di pusat dialisis di Kuala Lumpur, Malaysia. Objektif kajian ini adalah untuk menentukan hubungan antara dos dialisis dengan faktor demografi. Kedua, kajian ini juga ingin menentukan hubungan antara parameter biokimia dan faktor demografi. Parameter biokimia adalah serum albumin, kreatinin, kolesterol dan hemoglobin. Hasil kajian menunjukkan bahawa kesemua pesakit berbangsa India dan 54% pesakit berbangsa Cina mencapai dos dialisis yang diperlukan. Walau bagaimanapun, hanya 29% pesakit berbangsa Melayu mencapai dos yang efektif. Lebih ramai pesakit wanita yang mencapai dos dialisis sekurang-kurangnya 1.2 berbanding dengan pesakit lelaki dengan nisbah odds 11.24. Kesemua parameter biokimia adalah tidak bersandar dengan faktor demografi. Walau bagaimanapun aras kolesterol mempunyai hubungan yang signifikan dengan faktor jantina (p<0.05). Kesimpulannya, kajian ini menunjukkan bahawa parameter biokimia dan dos dialisis tidak mempunyai perkaitan dengan faktor demografi.

Kata kunci: Dos dialisis; hemodialisis; kegagalan renal peringkat lewat; parameter biokimia

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*Corresponding author; email: nurza@medic.ukm.my